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Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon
المؤلفون المشاركون
Abd al-Jawad, Iman A.
Hasanayn, Hala M. R.
Bahjat, Nahlah A.
Abd al-Sattar, Muna A.
al-Tawil, Maha A.
Hilal, Amani M.
al-Sisi, Azzah H.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 20، العدد 3 (30 سبتمبر/أيلول 2008)، ص ص. 216-223، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2008-09-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose : The levels of endothelin-1 and VEGF were evaluated in the sera of newly diagnosed patients with cancer colon and were compared with the routinely used tumor markers; CEA and CA19.9.
Their relations with some prognostic factors of cancer colon were also investigated.
Subjects and Methods : The study included 48 patients with cancer colon and 20 apparently healthy volunteers as a control group.
Patients were 23 males and 25 females with age range from 18 to 71 years (mean = 47±1.8).
Both serum and plasma samples were obtained from patients and controls.
Results : Six percent of patients had grade 1 tumors, 77% had grade 2 and 17% had grade 3 disease.
As regard to the stage, 52% of patients were stage II, 35.5% were stage III, while 12.5% were stage IV.
Liver metastasis was present in 12.5%, while 35% showed lymph node metastasis.
The VEGF, endothelin-1, CA19.9 and CEA were significantly higher in the cancer colon patients than in control groups (p-value <0.001, 0.006, <0.001 and <0.001; respectively).
Plasma level of endothelin-1 and serum level of VEGF showed significantly higher levels in advanced stages of the disease (p value <0 .001) and in presence of liver metastasis (p value <0.00l & 0.002 respectively), while VEGF showed significant result when compared with the grade (p value=0.032).
In this study, when comparing the levels of plasma endothelin-1 and serum VEGF between the metastatic, non-metastatic liver patients of the cancer colon group and the control group, the comparison was statistically significant for both markers (p<0.001).
Endothelin-1 and VEGF showed significant positive correlation (r=0.77 and p-value <0.0001).
Serum VEGF and CA19.9 showed good sensitivities which were not different (97.9% and 87.5%; respectively), while there was no significant difference between VEGF, CA19.9 and CEA with respect to specificities (100%, 90% and 100% respectively).
Conclusion : Both endothelin-1 and VEGF may be used for early detection of liver metastasis in cancer colon and VEGF may be used as a potential new marker for the diagnosis of cancer colon.
Further studies with larger number of patients are recommended to establish the value of VEGF and endothelin- 1 as potential diagnostic and prognostic markers for cancer colon.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Jawad, Iman A.& Hasanayn, Hala M. R.& Bahjat, Nahlah A.& Abd al-Sattar, Muna A.& al-Sisi, Azzah H.& al-Tawil, Maha A.…[et al.]. 2008. Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 3, pp.216-223.
https://search.emarefa.net/detail/BIM-355866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Jawad, Iman A.…[et al.]. Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon. Journal of the Egyptian National Cancer Institute Vol. 20, no. 3 (Sep. 2008), pp.216-223.
https://search.emarefa.net/detail/BIM-355866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Jawad, Iman A.& Hasanayn, Hala M. R.& Bahjat, Nahlah A.& Abd al-Sattar, Muna A.& al-Sisi, Azzah H.& al-Tawil, Maha A.…[et al.]. Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 3, pp.216-223.
https://search.emarefa.net/detail/BIM-355866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 221-223
رقم السجل
BIM-355866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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