Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon
المؤلفون المشاركون
Abd al-Jawad, Iman A.
Hasanayn, Hala M. R.
Bahjat, Nahlah A.
Abd al-Sattar, Muna A.
al-Tawil, Maha A.
Hilal, Amani M.
al-Sisi, Azzah H.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 20، العدد 3 (30 سبتمبر/أيلول 2008)، ص ص. 216-223، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2008-09-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose : The levels of endothelin-1 and VEGF were evaluated in the sera of newly diagnosed patients with cancer colon and were compared with the routinely used tumor markers; CEA and CA19.9.
Their relations with some prognostic factors of cancer colon were also investigated.
Subjects and Methods : The study included 48 patients with cancer colon and 20 apparently healthy volunteers as a control group.
Patients were 23 males and 25 females with age range from 18 to 71 years (mean = 47±1.8).
Both serum and plasma samples were obtained from patients and controls.
Results : Six percent of patients had grade 1 tumors, 77% had grade 2 and 17% had grade 3 disease.
As regard to the stage, 52% of patients were stage II, 35.5% were stage III, while 12.5% were stage IV.
Liver metastasis was present in 12.5%, while 35% showed lymph node metastasis.
The VEGF, endothelin-1, CA19.9 and CEA were significantly higher in the cancer colon patients than in control groups (p-value <0.001, 0.006, <0.001 and <0.001; respectively).
Plasma level of endothelin-1 and serum level of VEGF showed significantly higher levels in advanced stages of the disease (p value <0 .001) and in presence of liver metastasis (p value <0.00l & 0.002 respectively), while VEGF showed significant result when compared with the grade (p value=0.032).
In this study, when comparing the levels of plasma endothelin-1 and serum VEGF between the metastatic, non-metastatic liver patients of the cancer colon group and the control group, the comparison was statistically significant for both markers (p<0.001).
Endothelin-1 and VEGF showed significant positive correlation (r=0.77 and p-value <0.0001).
Serum VEGF and CA19.9 showed good sensitivities which were not different (97.9% and 87.5%; respectively), while there was no significant difference between VEGF, CA19.9 and CEA with respect to specificities (100%, 90% and 100% respectively).
Conclusion : Both endothelin-1 and VEGF may be used for early detection of liver metastasis in cancer colon and VEGF may be used as a potential new marker for the diagnosis of cancer colon.
Further studies with larger number of patients are recommended to establish the value of VEGF and endothelin- 1 as potential diagnostic and prognostic markers for cancer colon.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Jawad, Iman A.& Hasanayn, Hala M. R.& Bahjat, Nahlah A.& Abd al-Sattar, Muna A.& al-Sisi, Azzah H.& al-Tawil, Maha A.…[et al.]. 2008. Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 3, pp.216-223.
https://search.emarefa.net/detail/BIM-355866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Jawad, Iman A.…[et al.]. Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon. Journal of the Egyptian National Cancer Institute Vol. 20, no. 3 (Sep. 2008), pp.216-223.
https://search.emarefa.net/detail/BIM-355866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Jawad, Iman A.& Hasanayn, Hala M. R.& Bahjat, Nahlah A.& Abd al-Sattar, Muna A.& al-Sisi, Azzah H.& al-Tawil, Maha A.…[et al.]. Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 3, pp.216-223.
https://search.emarefa.net/detail/BIM-355866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 221-223
رقم السجل
BIM-355866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر