Expression of glucose transporter 4 (GLUT4) is increased by cinnamaldehyde in C2C12 mouse muscle cells
المؤلفون المشاركون
Fathi, Muhammad
Nikzamir, Abd al-Rahim
Palangi, Ali Rida
Kheirollaha, Ali Rida
Tabar, Hashimi
Malakaskar, Ali Muhammad
Shahbazian, Hajieh
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 2 (28 فبراير/شباط 2014)، ص ص. 1-5، 5ص.
الناشر
تاريخ النشر
2014-02-28
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: In diabetes mellitus because of the absence or insufficient sensitivity to insulin, glucose transporter protein in cell membrane, glucose transporter 4, is decreased.
GLUT4 is the major glucose transporter in skeletal muscle and adipose tissue, which is under control of insulin.
It remains, however, unclear whether cinnamaldehyde plays a regulatory role(s) or not.
Objectives: The objective of this study was to investigate the effects of cinnamaldehyde on GLUT4 gene expression.
Materials and Methods: This study was an experimental trial.
Tests were performed in triplicates.
This study examined effects of cinnamaldehyde on Glut4 gene expression in C2C12 skeletal muscle cells by using Real Time PCR.
C2C12 myoblasts were cultured in DMEM + 10 % FBS.
After differentiation of myoblasts to myotubes, the cells were serum deprived for 5 hours and then treated with 10, 20, or 50 μM of cinnamaldehyde for 1 hour.
Results: Our data revealed a significant increase in the expression of Glut4 in cinnamaldehyde treated cells.
In addition, GLUT4 mRNA level was increased in a dose dependent manner.
Analyses were performed using the SPSS 16 for Windows software.
Differences between the groups were determined by one-way ANOVA.
Conclusions: These results demonstrate that cinnamaldehyde up regulates the expression of mouse skeletal muscle GLUT4 gene expression.-
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nikzamir, Abd al-Rahim& Palangi, Ali Rida& Kheirollaha, Ali Rida& Tabar, Hashimi& Malakaskar, Ali Muhammad& Shahbazian, Hajieh…[et al.]. 2014. Expression of glucose transporter 4 (GLUT4) is increased by cinnamaldehyde in C2C12 mouse muscle cells. Iranian Red Crescent Medical Journal،Vol. 16, no. 2, pp.1-5.
https://search.emarefa.net/detail/BIM-355904
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nikzamir, Abd al-Rahim…[et al.]. Expression of glucose transporter 4 (GLUT4) is increased by cinnamaldehyde in C2C12 mouse muscle cells. Iranian Red Crescent Medical Journal Vol. 16, no. 2 (Feb. 2014), pp.1-5.
https://search.emarefa.net/detail/BIM-355904
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nikzamir, Abd al-Rahim& Palangi, Ali Rida& Kheirollaha, Ali Rida& Tabar, Hashimi& Malakaskar, Ali Muhammad& Shahbazian, Hajieh…[et al.]. Expression of glucose transporter 4 (GLUT4) is increased by cinnamaldehyde in C2C12 mouse muscle cells. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 2, pp.1-5.
https://search.emarefa.net/detail/BIM-355904
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5
رقم السجل
BIM-355904
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر