Association between XRCC1 G399A polymorphism and late complications to radiotherapy in Saudi head and neck cancer patients
المؤلفون المشاركون
al-Subayh, Ghazi Atiyyah
al-Subayi, Midhat Muhammad
al-Rajihi, Nasir Muhammad
al-Harbi, Najla Muhammad
al-Hadyan, Khalid Salih
al-Buhayri, Munirah Hamad
Miftah, Bilal Ali
al-Shabanah, Muhammad Uthman
Abu Amiru, Khalid Qadir
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 20، العدد 3 (30 سبتمبر/أيلول 2008)، ص ص. 302-308، 7ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2008-09-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : It has been hypothesized that patient to patient variation in normal tissue reactions to radiotherapy is associated with the presence of polymorphic variations in genes involved in DNA repair.
Purpose : To test for a possible association between two single-nucleotide polymorphisms (SNPs), XRCC1 399 G>A Arg/Gln and XRCC3 241 C>T Thr/Met and late reactions to radiotherapy.
Patients and Methods : In this case control study, 50 Head and Neck cancer patients were retrospectively recruited.
The grade (G) of fibrosis, a late complication to radiotherapy, was scored using the RTOG / EORTC grading system.
Radiosensitive patients with moderate to severe subcutaneous and deep tissue fibrosis (cases, G2-3, n = 25) where matched with patients with minimal fibrotic reactions (control, G0-1, n=25).
The two nonsynonymous SNPs were genotyped by direct sequencing of DNA extracted from blood or cultured fibroblasts.
Results: Allelic frequency showed significant association with grade of fibrosis for XRCC1 399 G/A (p = 0.05), but not for XRCC3 241 C>T (p = 0.10).
Conclusions : This pilot study corroborates the association between XRCC1 399 G>A and risk of late normal tissue complications following radiotherapy in our patients.
Large studies are required to unravel more SNPs that can influence radiosensitivity and ascertain the associations with reactions to radiotherapy in order to be used as genetic predictive biomarkers of individual radiosensitivity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Subayh, Ghazi Atiyyah& al-Subayi, Midhat Muhammad& al-Rajihi, Nasir Muhammad& al-Harbi, Najla Muhammad& al-Hadyan, Khalid Salih& al-Buhayri, Munirah Hamad…[et al.]. 2008. Association between XRCC1 G399A polymorphism and late complications to radiotherapy in Saudi head and neck cancer patients. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 3, pp.302-308.
https://search.emarefa.net/detail/BIM-355921
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Subayh, Ghazi Atiyyah…[et al.]. Association between XRCC1 G399A polymorphism and late complications to radiotherapy in Saudi head and neck cancer patients. Journal of the Egyptian National Cancer Institute Vol. 20, no. 3 (Sep. 2008), pp.302-308.
https://search.emarefa.net/detail/BIM-355921
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Subayh, Ghazi Atiyyah& al-Subayi, Midhat Muhammad& al-Rajihi, Nasir Muhammad& al-Harbi, Najla Muhammad& al-Hadyan, Khalid Salih& al-Buhayri, Munirah Hamad…[et al.]. Association between XRCC1 G399A polymorphism and late complications to radiotherapy in Saudi head and neck cancer patients. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 3, pp.302-308.
https://search.emarefa.net/detail/BIM-355921
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 308
رقم السجل
BIM-355921
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر