The effect of treatment with N-acetylcysteine on the serum levels of C-reactive protein and interleukin-6 in patients on hemodialysis
المؤلفون المشاركون
Saddadi, Fereshteh
Alatab, Sudabeh
Pasha, Farahnaz
Ganji, Muhammad Rida
Soleimanian, Tayebeh
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 25، العدد 1 (28 فبراير/شباط 2014)، ص ص. 66-72، 7ص.
الناشر
تاريخ النشر
2014-02-28
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Patients with end-stage renal disease (ESRD) are at an increased risk of cardiovascular disease due to many factors including inflammation and oxidative stress.
N-acetylcysteine (NAC) is a thiol-containing anti-oxidant with anti-inflammatory properties.
We aimed to assess the effect of three months treatment with oral NAC on the plasma levels of inflammatory mediators like interleukin-6 (IL-6) and C-reactive protein (hs-CRP) in patients on hemodialysis (HD).
Twenty-four patients (nine males and 15 females) on maintenance HD were recruited in the study.
Their mean age was 55.3 years.
All the patients received oral NAC (600 mg twice a day) for a period of three months.
The serum levels of biomedical parameters and IL-6 and hs-CRP were measured at baseline and three months after initiation of treatment.
A significant decrease in serum levels of hs-CRP (22.4 vs.
5.2), IL-6 (8.1 vs.
3.6), parathyroid hormone (iPTH) (257.2 vs.
158.8), ferritin (632.0 vs.
515.1) and erythrocyte sedimentation rate (ESR) (54.2 vs.
38.3) was observed following NAC treatment.
Female subjects presented with a significantly higher change in serum levels of hs-CRP compared with males (23 vs.
5.4).
In three subjects who were less than 40 years old, the hs-CRP and IL-6 levels showed an increase following NAC treatment.
Our study found that short-term oral NAC treatment might result in the reduction of IL-6 and hs-CRP in patients who are on regular HD.
This suggests that patients with ESRD may benefit from the antiinflammatory effects of NAC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saddadi, Fereshteh& Alatab, Sudabeh& Pasha, Farahnaz& Ganji, Muhammad Rida& Soleimanian, Tayebeh. 2014. The effect of treatment with N-acetylcysteine on the serum levels of C-reactive protein and interleukin-6 in patients on hemodialysis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 1, pp.66-72.
https://search.emarefa.net/detail/BIM-356638
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saddadi, Fereshteh…[et al.]. The effect of treatment with N-acetylcysteine on the serum levels of C-reactive protein and interleukin-6 in patients on hemodialysis. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 1 (Jan. / Feb. 2014), pp.66-72.
https://search.emarefa.net/detail/BIM-356638
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saddadi, Fereshteh& Alatab, Sudabeh& Pasha, Farahnaz& Ganji, Muhammad Rida& Soleimanian, Tayebeh. The effect of treatment with N-acetylcysteine on the serum levels of C-reactive protein and interleukin-6 in patients on hemodialysis. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 1, pp.66-72.
https://search.emarefa.net/detail/BIM-356638
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 71-72
رقم السجل
BIM-356638
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر