Correlation and identification of variable number of tandem repeats of eNOS Gene in coronary artery disease (CAD)
المؤلفون المشاركون
Rabbani, Sayyid Imam
Biyabani, Muin al-Din
Prasad, Shiva
Diba, Farha
Jamil, Qaisar
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 17، العدد 3 (31 يوليو/تموز 2010)، ص ص. 209-213، 5ص.
الناشر
تاريخ النشر
2010-07-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Endothelium-derived nitric oxide (NO) is synthesized from L-arginine by endothelial nitric oxide synthase (eNOS) encoded by the NOS3 gene on chromosome7.
Since reduced NO synthesis has been implicated in the development of coronary atherosclerosis ; polymorphisms of NOS gene might be associated with increased susceptibility to coronary artery disease (CAD).
We therefore undertook this study to determine the association between the occurrence of CAD and eNOS4 b / a polymorphism in South Indian patients.
We investigated the polymorphisms in the 27 base-pair tandem repeats in intron4 of the eNOS gene in 100 unrelated CAD patients with positive coronary angiograms and 100 age and sex matched control subjects without any history of symptomatic CAD.
The eNOS gene intron4 b / a VNTR polymorphism was analyzed by polymerase chain reaction.
The plasma lipids levels and other risk factors were also determined.
The genotype frequencies for eNOS4b / b, eNOS4a / b and eNOS4a / a were 63, 26 and 11 per cent in CAD subjects, and 72, 20 and 8 per cent in control subjects, respectively.
The genotype frequencies did not differ significantly between the two groups.
The frequency of the a allele was 0.24 per cent in CAD subjects and 0.18 per cent in control subjects and no significant association was found between patients and control group (P = 0.57, Odds ratio = 3.62).
Plasma lipids, glucose and creatinine levels were significantly increased in CAD group.
The genotypic frequencies and the allele frequency did not differ significantly between the CAD patients and controls indicating that this polymorphism was not an independent risk factor for the development of CAD in South Indian patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rabbani, Sayyid Imam& Biyabani, Muin al-Din& Prasad, Shiva& Diba, Farha& Jamil, Qaisar. 2010. Correlation and identification of variable number of tandem repeats of eNOS Gene in coronary artery disease (CAD). Saudi Journal of Biological Sciences،Vol. 17, no. 3, pp.209-213.
https://search.emarefa.net/detail/BIM-357787
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rabbani, Sayyid Imam…[et al.]. Correlation and identification of variable number of tandem repeats of eNOS Gene in coronary artery disease (CAD). Saudi Journal of Biological Sciences Vol. 17, no. 3 (Jul. 2010), pp.209-213.
https://search.emarefa.net/detail/BIM-357787
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rabbani, Sayyid Imam& Biyabani, Muin al-Din& Prasad, Shiva& Diba, Farha& Jamil, Qaisar. Correlation and identification of variable number of tandem repeats of eNOS Gene in coronary artery disease (CAD). Saudi Journal of Biological Sciences. 2010. Vol. 17, no. 3, pp.209-213.
https://search.emarefa.net/detail/BIM-357787
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 212-213
رقم السجل
BIM-357787
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر