Protective effects of curcumin against lithium–pilocarpine induced status epilepticus, cognitive dysfunction and oxidative stress in young rats
المؤلف
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 20، العدد 2 (30 إبريل/نيسان 2013)، ص ص. 155-162، 8ص.
الناشر
تاريخ النشر
2013-04-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
-Status epilepticus (SE), one of the most severe forms of epilepsy is regarded a medical emergency with considerable morbidity and mortality.
Due to the limited efficacy and enormous side effects of currently available drugs, a search for new safe and effective therapeutic agents is critical using experimentally induced SE in animals.
The lithium–pilocarpine (Li–Pc) model of SE is most suitable and frequently used for pathophysiological and management strategies of SE.
Recent studies have shown significant potential of pharmacological, prophylactic or therapeutic use of curcumin (Cur) in many beneficial activities in the body including neuroprotection in neurodegenerative diseases and antioxidant properties.
The present study describes anticonvulsive effects of Cur in Li–Pc induced SE in young rats.
The effect of Cur was examined on the intensity and frequency of SE, cognitive behavior in water maze as well as on oxidative stress related enzymes in the brain.
Besides its anticonvulsant effect, Cur significantly ameliorates SE-induced cognitive dysfunction and oxidative damages in the hippocampus and striatum areas of the brain.
Possible therapeutic application of Cur as an anticonvulsant and as an antioxidant for the treatment of SE has a great potential and warrants further studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Muhammad. 2013. Protective effects of curcumin against lithium–pilocarpine induced status epilepticus, cognitive dysfunction and oxidative stress in young rats. Saudi Journal of Biological Sciences،Vol. 20, no. 2, pp.155-162.
https://search.emarefa.net/detail/BIM-357837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Muhammad. Protective effects of curcumin against lithium–pilocarpine induced status epilepticus, cognitive dysfunction and oxidative stress in young rats. Saudi Journal of Biological Sciences Vol. 20, no. 2 (Apr. 2013), pp.155-162.
https://search.emarefa.net/detail/BIM-357837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Muhammad. Protective effects of curcumin against lithium–pilocarpine induced status epilepticus, cognitive dysfunction and oxidative stress in young rats. Saudi Journal of Biological Sciences. 2013. Vol. 20, no. 2, pp.155-162.
https://search.emarefa.net/detail/BIM-357837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 161-162
رقم السجل
BIM-357837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر