A study of the M235T variant of the angiotensinogen gene and hypertension in a sample population of Calabar and Uyo, Nigeria
المؤلفون المشاركون
Kooffreh, Mary E.
Anumudu, Chiaka I.
Akpan, Effiong E.
Ikpeme, Eke V.
Kumar, P. Lava
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 14، العدد 1 (31 يناير/كانون الثاني 2013)، ص ص. 13-19، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2013-01-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
A common molecular variant of the angiotensinogen gene had been reported to predispose some ethnic groups to hypertension.
This case–control study was designed to determine the frequency and association of the angiotensinogen M235T allele with hypertension in residents of Calabar and Uyo cities, south–south Nigeria.
The study involved 1308 subjects, 612 patients and 696 controls.
The M235T variant was investigated using an allele specific polymerase chain reaction and enzymatic digestion to determine allele frequencies.
Hypertensinogenic factors such as dietary habits, physical activity, smoking and drinking habits were assessed using questionnaires.
Descriptive statistics, chi-square and multiple regression analysis were used to analyze the data obtained.
The M235T allele frequency was high (0.94 for hypertensives and 0.96 for controls) though it was not associated with hypertension status.
The odds ratio for hypertension was 0.64 (95 % confidence interval : 0.39–1.06) there were no significant differences between the genotype frequency of hypertensives and controls.
By multiple regression, Hypertension was observed to be associated with age and was a predictor for systolic blood pressure in both patient r2 = 0.359 ; p < 0.05 and control groups r2 = 0.26.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kooffreh, Mary E.& Anumudu, Chiaka I.& Akpan, Effiong E.& Ikpeme, Eke V.& Kumar, P. Lava. 2013. A study of the M235T variant of the angiotensinogen gene and hypertension in a sample population of Calabar and Uyo, Nigeria. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 1, pp.13-19.
https://search.emarefa.net/detail/BIM-357948
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kooffreh, Mary E.…[et al.]. A study of the M235T variant of the angiotensinogen gene and hypertension in a sample population of Calabar and Uyo, Nigeria. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 1 (Jan. 2013), pp.13-19.
https://search.emarefa.net/detail/BIM-357948
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kooffreh, Mary E.& Anumudu, Chiaka I.& Akpan, Effiong E.& Ikpeme, Eke V.& Kumar, P. Lava. A study of the M235T variant of the angiotensinogen gene and hypertension in a sample population of Calabar and Uyo, Nigeria. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 1, pp.13-19.
https://search.emarefa.net/detail/BIM-357948
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 18-19
رقم السجل
BIM-357948
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر