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Antigenotoxic and anticytotoxic effect of camel milk in mice treated with cisplatin
المؤلفون المشاركون
Salwa, M. Quita
Lina, A. F. Kurdi
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 17، العدد 2 (30 إبريل/نيسان 2010)، ص ص. 159-166، 8ص.
الناشر
تاريخ النشر
2010-04-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Camel milk (CM) has good nutritive value, in addition to its antigenotoxic and anticytotoxic effects.
Therefore the aim of this investigation was to evaluate the capacity of CM to inhibit the micronucleated polychromatic erythrocytes (MnPCEs) in the bone marrow and improve the mitotic activity produced by cisplatin.
Cisplatin is one of the most widely used antineoplastic drugs in the treatment of cancer.
The 70 adult male Swiss albino mice were divided into seven groups : Gr.
I : treated with distilled water and considered as a control group. Gr.
II : treated with camel milk (33 ml / kg, b.
w). Gr.
III : treated previously with cisplatin (0.5 mg / kg, b.
w). Gr.
IV : treated with camel milk and followed after 2 h.
with cisplatin (33 ml / kg fi 0.5 mg / kg, b.
w). Gr.
V : treated with camel milk and cisplatin at the same time (33 ml / kg +0.5 mg / kg, b.
w). Gr.
VI : treated with an acute single dose of cisplatin (2.5 mg / kg, b.
w). Gr.
VII : treated with camel milk prior and followed with an acute single dose of cisplatin (33 ml / kg fi 2.5 mg / kg, b.
w).
The animals were sacrificed 24 h after cisplatin injection.
The pretreatment with CM dose caused a significant decrease (P < 0.001) in the frequency of MnPCEs and increase (P < 0.001) in the mitotic index (MI) induced by cisplatin when compared with the groups treated with cisplatin alone.
The possible explanation for the antigenotoxic and anticytotoxic effects observed in the pretreatment with CM is ascribed to its contents.
In conclusion, from the findings we suggest that this milk has some antioxidant effect, and the antigenotoxic mechanism of this milk needs to be explored further before their use during cisplatin chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salwa, M. Quita& Lina, A. F. Kurdi. 2010. Antigenotoxic and anticytotoxic effect of camel milk in mice treated with cisplatin. Saudi Journal of Biological Sciences،Vol. 17, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-358332
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salwa, M. Quita& Lina, A. F. Kurdi. Antigenotoxic and anticytotoxic effect of camel milk in mice treated with cisplatin. Saudi Journal of Biological Sciences Vol. 17, no. 2 (Apr. 2010), pp.159-166.
https://search.emarefa.net/detail/BIM-358332
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salwa, M. Quita& Lina, A. F. Kurdi. Antigenotoxic and anticytotoxic effect of camel milk in mice treated with cisplatin. Saudi Journal of Biological Sciences. 2010. Vol. 17, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-358332
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 165-166
رقم السجل
BIM-358332
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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