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Study of the possible cardio protective effects of insulin, ATP, and L-arginine against isoproterenol-induced myocardial infarction
المؤلفون المشاركون
Muhammad, Fatimah A.
Ahmad, Muna Abbas
Abd al-Hadi, Inas Ahmad
Abd al-Salam, Muhammad F.
Ayyubi, Mahmud H.
المصدر
Journal of the Arab Society for Medical Research
العدد
المجلد 8، العدد 1 (30 يونيو/حزيران 2013)، ص ص. 12-18، 7ص.
الناشر
تاريخ النشر
2013-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Acute myocardial infarction remains a leading cause of morbidity and mortality worldwide.
The present study was carried out to investigate the possible protective effects of insulin, ATP, and L-arginine on cardiac dysfunction in experimental isoproterenol (ISO)-induced myocardial infarction (MI), aiming at achieving useful means for protection and therapy against MI.
Materials and methods Wistar rats of both sexes were allocated into five groups: the control group, the untreated MI group, and MI groups treated with insulin, ATP, or L-arginine.
All rats were subjected to ECG recording, and plasma levels of troponin I and triglycerides were determined.
The isolated perfused hearts, according to Langendorff’s preparation, were studied; the left ventricular weight (LV) was determined, and the LV per body weight ratio (LV/BW) was calculated.
Results The percentage mortality and total arrhythmia were significantly reduced upon treatment with ATP and L-arginine.
The ST segment elevation was significantly reduced in insulin-treated rats.
The QRS duration and QTo intervals were significantly decreased in ATP-treated and L-arginine-treated rats, and the QTc interval was significantly shortened in all three treated groups.
The levels of plasma triglycerides significantly reduced on treatment with insulin and ATP.
In the three treated groups, the peak developed tension baseline value and maximal response were significantly increased when compared with the untreated group.
In addition, the half-relaxation time baseline value was significantly decreased in the treated groups when compared with the control group.
The myocardial flow rate baseline value and maximal response were significantly increased on L-arginine treatment.
The LV weights and LV/BW ratios were significantly increased in all three treated groups.
Conclusion Insulin, ATP, and L-arginine were variably effective in partially modifying the ISO-induced MI insults and offered partial protection against ISO-induced myocardial damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Fatimah A.& Ahmad, Muna Abbas& Abd al-Hadi, Inas Ahmad& Abd al-Salam, Muhammad F.& Ayyubi, Mahmud H.. 2013. Study of the possible cardio protective effects of insulin, ATP, and L-arginine against isoproterenol-induced myocardial infarction. Journal of the Arab Society for Medical Research،Vol. 8, no. 1, pp.12-18.
https://search.emarefa.net/detail/BIM-358871
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Fatimah A.…[et al.]. Study of the possible cardio protective effects of insulin, ATP, and L-arginine against isoproterenol-induced myocardial infarction. Journal of the Arab Society for Medical Research Vol. 8, no. 1 (2013), pp.12-18.
https://search.emarefa.net/detail/BIM-358871
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Fatimah A.& Ahmad, Muna Abbas& Abd al-Hadi, Inas Ahmad& Abd al-Salam, Muhammad F.& Ayyubi, Mahmud H.. Study of the possible cardio protective effects of insulin, ATP, and L-arginine against isoproterenol-induced myocardial infarction. Journal of the Arab Society for Medical Research. 2013. Vol. 8, no. 1, pp.12-18.
https://search.emarefa.net/detail/BIM-358871
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 18
رقم السجل
BIM-358871
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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