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Effect of oxytocin on duodenal motility in female rats
المؤلفون المشاركون
Ahmad, Muna Abbas
Abbud, Atif M. M.
المصدر
Journal of the Arab Society for Medical Research
العدد
المجلد 7، العدد 2 (31 ديسمبر/كانون الأول 2012)، ص ص. 73-77، 5ص.
الناشر
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Reports on the effect of oxytocin on intestinal motility have shown controversial results in human and animal studies.
The aim of the study was to investigate the effect of oxytocin on duodenal motility in normal female Wistar rats in vivo and in vitro.
Materials and methods : A total of 30 adult female Wistar albino rats were divided into three groups : the control group ; the oxytocin-treated group (5 mg / kg body weight injected intraperitoneally for 7 days) ; and the in-vitro oxytocin group, in which the effect of four doses of oxytocin (0.022, 0.11, 0.22, and 1.1 mg / bath) added to the organ bath was studied.
The isometric contractile response of isolated segments of duodenum was recorded with respect to the frequency of contraction, the average duration of contraction, the average force of contraction, and the motility index.
Results : Oxytocin-treated rats showed a significant increase in the duodenum average force of contraction (P < 0.05) and motility index (P < 0.01) and a decrease in the frequency of contraction (P < 0.05) as compared with the control group.
Low doses of oxytocin administered in vitro (0.022 and 0.11 mg / bath) resulted in a significant increase in the duodenum average force of contraction (P < 0.05) and motility index (P < 0.05) when compared with their respective baseline values, whereas higher doses caused either insignificant changes in the motility parameters at a dose of 0.22 mg / bath or a significant decrease in the duodenum average force of contraction (P < 0.01) and motility index (P < 0.01) at a dose of 1.1 mg/bath when compared with their baseline values.
Conclusion : Oxytocin treatment enhanced duodenal motility in adult female Wistar rats.
Higher doses of oxytocin inhibit duodenal motility, which may be explained by an indirect mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abbud, Atif M. M.& Ahmad, Muna Abbas. 2012. Effect of oxytocin on duodenal motility in female rats. Journal of the Arab Society for Medical Research،Vol. 7, no. 2, pp.73-77.
https://search.emarefa.net/detail/BIM-359062
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abbud, Atif M. M.& Ahmad, Muna Abbas. Effect of oxytocin on duodenal motility in female rats. Journal of the Arab Society for Medical Research Vol. 7, no. 2 (2012), pp.73-77.
https://search.emarefa.net/detail/BIM-359062
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abbud, Atif M. M.& Ahmad, Muna Abbas. Effect of oxytocin on duodenal motility in female rats. Journal of the Arab Society for Medical Research. 2012. Vol. 7, no. 2, pp.73-77.
https://search.emarefa.net/detail/BIM-359062
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 77
رقم السجل
BIM-359062
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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