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Analysis of aromatase (CYP19) gene in Iranian women with endometriosis
المؤلفون المشاركون
Sabir, Hajir
Salihi, Zivar
Sadri, Saidah
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 14، العدد 2 (30 إبريل/نيسان 2013)، ص ص. 165-169، 5ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2013-04-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Endometriosis is a chronic, inflammatory, estrogen dependent disease that affects up to 10 % of all women of fertile age.
It is characterized by the presence and proliferation of functional endometrial glands and stroma outside the uterine cavity.
The aim of this study was to assess whether intron 4 (TTTA)n repeat and TCT deletion / insertion polymorphisms of CYP19 gene are associated with endometriosis in northern Iran.
This study involved 110 patients with endometriosis and 200 healthy controls, who were genotyped for (TTTA) repeats in the fourth intron of the CYP19 gene.
Genomic DNA from patients and controls was genotyped by polymerase chain reaction (PCR).
A total of eight alleles were observed in our study population, ranging from 7 repeats to 13 repeats.
(TTTA) repeat lengths of 69 were classified as short (S), and those P10 were classified as long (L).
Compared to women who possessed the S / S genotype, those who carried L / L (OR, 5.56 ; 95 % CI, 3.33–9.29) had significantly increased risk of endometriosis.
There was a significant trend between L / L genotype and higher stage of endometriosis (P < 0.001).
In conclusion, a significant association was identified between endometriosis and the CYP19 gene polymorphism, with endometriosis having longer CYP19 repeat lengths than control subjects.
The strong association of CYP19 gene polymorphism with high-stage endometriosis suggests that CYP19 may have a prognostic implication.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sabir, Hajir& Salihi, Zivar& Sadri, Saidah. 2013. Analysis of aromatase (CYP19) gene in Iranian women with endometriosis. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 2, pp.165-169.
https://search.emarefa.net/detail/BIM-359426
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sabir, Hajir…[et al.]. Analysis of aromatase (CYP19) gene in Iranian women with endometriosis. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 2 (Apr. 2013), pp.165-169.
https://search.emarefa.net/detail/BIM-359426
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sabir, Hajir& Salihi, Zivar& Sadri, Saidah. Analysis of aromatase (CYP19) gene in Iranian women with endometriosis. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 2, pp.165-169.
https://search.emarefa.net/detail/BIM-359426
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 168-169
رقم السجل
BIM-359426
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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