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Terminalia arjuna, a herbal remedy against environmental carcinogenicity : an in vitro and in vivo study
المؤلفون المشاركون
Afzal, Muhammad
Ahmad, Muhammad Sultan
Ahmad, Shaybah
Gautam, Brijraj
Arshad, Muhammad
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 15، العدد 1 (31 يناير/كانون الثاني 2014)، ص ص. 61-67، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2014-01-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Medicinal plants have been a major source of therapeutic agents from ancient times to cure diseases.
The evaluation of rich heritage of traditional medicine is essential.
The bark of Terminalia arjuna is rich in polyphenols (60–70 %) including flavonoids and tannins.
Aim : The aim of the present investigation is to highlight the anticarcinogenic and antimutagenic potential of extracts of T.
arjuna.
Subject and methods : In this experiment we have used human lymphocyte culture and bone marrow cells of albino mice as assay system.
The parameters studied included chromosomal aberrations (CA), sister chromatid exchanges (SCEs) and cell growth kinetics (RI) both in the presence and in the absence of exogenous metabolic activation system for in vitro experiment, whereas total aberrant cells and the total frequencies of aberrations were taken for in vivo study.
Results: The role of T.
arjuna extracts in reducing metaphase aberrations due to aflatoxin B1 is quite significant, the reduction varying from 23.49 %, 42.47 %, and 59.65 % down to 12.32 %, 28.00 %, and 36.88 % respectively at the highest dose (TA4) for the three different durations viz., 24, 48 and 72 h.
Similarly the number of sister chromatid exchanges got reduced from a higher level of 15.00 ± 1.40 per cell to 7.70 ± 0.50 per cell with S9 mix at 48 h of treatment.
The replication index was enhanced from 1.33 to 1.55 in vitro.
Similar trends were noticed in the in vivo experiments i.e., effective reductions in clastogeny ranging from 15.22 % to 54.82 % from the mutagen treated positive control and the total frequencies in aberrant cells got reduced from 429 due to AFB1 to 141 due to 5th concentration of Terminalia extracts at 32 h of exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Muhammad Sultan& Ahmad, Shaybah& Gautam, Brijraj& Arshad, Muhammad& Afzal, Muhammad. 2014. Terminalia arjuna, a herbal remedy against environmental carcinogenicity : an in vitro and in vivo study. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 1, pp.61-67.
https://search.emarefa.net/detail/BIM-360537
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Muhammad Sultan…[et al.]. Terminalia arjuna, a herbal remedy against environmental carcinogenicity : an in vitro and in vivo study. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 1 (Jan. 2014), pp.61-67.
https://search.emarefa.net/detail/BIM-360537
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Muhammad Sultan& Ahmad, Shaybah& Gautam, Brijraj& Arshad, Muhammad& Afzal, Muhammad. Terminalia arjuna, a herbal remedy against environmental carcinogenicity : an in vitro and in vivo study. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 1, pp.61-67.
https://search.emarefa.net/detail/BIM-360537
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 67
رقم السجل
BIM-360537
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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