Serum level of interleukin-10 with its gene polymorphism can be predictors of response to treatment in Egyptian patients with chronic hepatitis C virus
المؤلفون المشاركون
Shahbah, Abir
al-Bassat, Hanan
Abu Ali, Lobna
Alam al-Din, Rasha A.
Hasbi, Iman
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 14، العدد 3 (31 يوليو/تموز 2013)، ص ص. 227-233، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2013-07-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose : The aim of this study was to demonstrate the role of interleukin-10 (IL-10) gene polymorphism and its serum level in predicting response to treatment in patients with chronic hepatitis C virus.
Patients and methods : This study was carried out on 35 Egyptian patients with chronic HCV (Hepatitis C Virus) and 15 age- and sex-matched healthy subjects as control.
They were divided as follows : Group I : 35 chronic HCV patients.
They were subdivided according to their response to combination therapy of pegylated interferon alpha 2b and ribavirin into : Group I (a) : 21 responder patients.
Group I (b): 14 non responder patients.
Group II : 15 healthy subjects as a control group.
IL-10 serum level was assessed by ELISA (Enzyme Linked Immunosorbent Assay) before, during and after treatment.
IL-10 gene polymorphism and genotype were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results : A significant higher level of serum IL-10 was detected in HCV patients compared to the control group.
A significant reduction was detected during treatment and a persistent decrease was found in patients with SVR.
Low serum level of IL-10 pretreatment was associated with high treatment response.
High pretreatment of the serum level of IL-10 was associated with the severity of chronic necroinflammation and non response to treatment.
A positive correlation was found between IL-10 and serum ALT.
The frequency of IL-10 592 genotype polymorphism was higher in HCV patients compared to control.
A significant higher frequency of the IL-10 592 C / C polymorphism was found in the responder group compared to non responder.
No correlation was observed between IL-10 polymorphism and liver histopathology.
Conclusion : Serum IL-10 level pretreatment is useful for predicting treatment response in HCV patients.
IL-10 may be a useful marker to assess necroinflammation and to monitor the evolution of liver damage.
IL-10 gene polymorphism has no relation to liver histopathology.
IL-10 592 C / C genotype was more frequent in responder patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Bassat, Hanan& Abu Ali, Lobna& Alam al-Din, Rasha A.& Hasbi, Iman& Shahbah, Abir. 2013. Serum level of interleukin-10 with its gene polymorphism can be predictors of response to treatment in Egyptian patients with chronic hepatitis C virus. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 3, pp.227-233.
https://search.emarefa.net/detail/BIM-360736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Bassat, Hanan…[et al.]. Serum level of interleukin-10 with its gene polymorphism can be predictors of response to treatment in Egyptian patients with chronic hepatitis C virus. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 3 (Jul. 2013), pp.227-233.
https://search.emarefa.net/detail/BIM-360736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Bassat, Hanan& Abu Ali, Lobna& Alam al-Din, Rasha A.& Hasbi, Iman& Shahbah, Abir. Serum level of interleukin-10 with its gene polymorphism can be predictors of response to treatment in Egyptian patients with chronic hepatitis C virus. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 3, pp.227-233.
https://search.emarefa.net/detail/BIM-360736
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 232-233
رقم السجل
BIM-360736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر