Assessment of immune function in down syndrome patients
المؤلفون المشاركون
Abd al-Salam, Ekram
Korraa, Suhayr
Abd al-Majid, Iman
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 14، العدد 3 (31 يوليو/تموز 2013)، ص ص. 307-310، 4ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2013-07-31
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
In Down syndrome (DS), trisomy 21 leads to overexpression of gene coding for specific enzymes.
This overexpression translates directly into biochemical aberrations that affect multiple interacting metabolic pathways which culminates in cellular dysfunction and contributes to the unique pathogenesis of DS.
The aim of this study is to evaluate parameters of immune response in terms of cytokines [tumor necrosis factor-a (TNF-a) and interlukin-2 (IL-2)] together with the quantitative expression of cystathionine beta synthase (CBS), whose transsulfuration pathway generates cysteine and hydrogen sulfide (H2S).
H2S is known to boost host defense at physiological concentrations and to display cytotoxic activity at higher concentrations.
Calcineurin activity (CAN) was also measured as its dysregulation has been shown to cause immune suppression.
Subjects were 60 DS patients vs.
30 age and socioeconomic matching healthy controls.
In their blood, the cytokines : TNF-a and IL-2, together with CBS and its by product H2S as well as CAN activity, were measured.
Results showed that CBSmRNA relative expression (0.56 ± .06 vs.
0.32 ± .02), plasma H2S (72 ± 8.5 vs.
50.8 ± 4.1) and TNF-a (8.11 ± .01 vs.
3.6 ± 0.9) were significantly higher among DS patients compared to controls, while CAN (0.27 ± 0.1 vs.
0.45 ± 0.2 units), was significantly decreased in blood of DS patients compared to controls.
IL-2 (36.4 ± 2.6 vs.
37.4 ± 0.9) showed no significant difference between DS patients and controls.
Accordingly it can be concluded that excessive synthesis of multiple gene products derived from overexpression of the genes present on chromosome 21 may be the cause for decreased immunity in DS patients compared to controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Salam, Ekram& Abd al-Majid, Iman& Korraa, Suhayr. 2013. Assessment of immune function in down syndrome patients. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 3, pp.307-310.
https://search.emarefa.net/detail/BIM-360748
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Salam, Ekram…[et al.]. Assessment of immune function in down syndrome patients. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 3 (Jul. 2013), pp.307-310.
https://search.emarefa.net/detail/BIM-360748
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Salam, Ekram& Abd al-Majid, Iman& Korraa, Suhayr. Assessment of immune function in down syndrome patients. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 3, pp.307-310.
https://search.emarefa.net/detail/BIM-360748
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 309-310
رقم السجل
BIM-360748
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر