Role of bone in renal osteodystrophy
المؤلفون المشاركون
al-Badr, Wisam
Martin, Kavin J.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 20، العدد 1 (28 فبراير/شباط 2009)، ص ص. 12-19، 8ص.
الناشر
تاريخ النشر
2009-02-28
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Renal osteodystrophy (ROD), the abnormal bone histology that occurs in the context of kidney disease, is a disease spectrum and not a uniform progressive bone disease.
It is an important component of the broad disturbances of bone and mineral metabolism associated with chronic kidney disease (CKD).
There are multiple pathogenetic factors which contribute to the histological abnormalities seen on bone biopsy.
The patients with ROD are rarely symptomatic in the early stages of CKD.
It is also noteworthy that the clinical manifestations are usually preceded by biochemical changes that are insidious and subtle.
This makes it difficult for the clinician to suspect the presence of bone and mineral metabolism abnormalities without direct testing.
The serum calcium, phosphorus, and alkaline phosphatase levels are usually normal until late in the course of CKD.
The main screening test for abnormal bone and mineral metabolism is the measurement of parathyroid hormone which is also somewhat delayed.
The clinical signs and symptoms are also challenging to interpret because of their slow and non-specific nature which may include vague, ill-defined, bone aches and pains, and muscle weakness.
The gold standard for diagnosis of ROD is bone biopsy with mineralized bone histology after double tetracycline labeling, iron staining and aluminum staining.
The currently used histomorphometric descriptions of bone histology are not well integrated clinically and a new nomenclature that is clinically more relevant and useful has been proposed.
Additional studies are required to define the spectrum of ROD in the current therapeutic era, and to find clinically useful non-invasive biomarkers to improve the treatment and monitoring of the abnormal bone in the setting of CKD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Badr, Wisam& Martin, Kavin J.. 2009. Role of bone in renal osteodystrophy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 1, pp.12-19.
https://search.emarefa.net/detail/BIM-36080
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Badr, Wisam& Martin, Kavin J.. Role of bone in renal osteodystrophy. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 1 (Jan. 2009), pp.12-19.
https://search.emarefa.net/detail/BIM-36080
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Badr, Wisam& Martin, Kavin J.. Role of bone in renal osteodystrophy. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 1, pp.12-19.
https://search.emarefa.net/detail/BIM-36080
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 18-19
رقم السجل
BIM-36080
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر