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The impact of genetic polymorphisms on time required to attain the target tacrolimus levels and subsequent pharmacodynamic outcomes in pediatric kidney transplant patients
المؤلف
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 25، العدد 2 (30 إبريل/نيسان 2014)، ص ص. 266-277، 12ص.
الناشر
تاريخ النشر
2014-04-30
دولة النشر
السعودية
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Recent pharmacogenetic studies involving various transplant recipients in diverse ethnic populations revealed contradictory findings regarding the impact of CYP3A5 and multidrug resistance-1 (MDR1) single nucleotide polymorphisms (SNPs) on the pharmacodynamics of tacrolmius (TAC).
The aim of the current study was to evaluate the impact of these SNPs on the time required to attain target TAC levels and subsequent pharmacodynamic outcomes in pediatric kidney transplant patients.
Thirty-eight patients were genotyped for CYP3A5*1 and *3, and MDR1 C3435T.
Notably, none of the patients expressing CYP3A5 *1*1 or *1*3 achieved the target concentration of 10–20 ng / mL within the first 2 weeks or even the first month after transplant.
However, 34.4 % of CYP3A5 *3*3 achieved and maintained the target goal within the first and second weeks (P < 0.05).
In contrast, C3435T polymorphism had no significant influence on the proportion of patients achieving target TAC levels.
An examination of the impact of genotype combinations on clinical outcomes revealed an increased incidence of acute, chronic rejection and graft loss in patients carrying heterozygous MDR1 C3435T alleles (CT) ; this indicates the possibility of an additive effect of this SNP on its concurrent combination with a *3*3 SNP.
In conclusion, our study revealed trends toward unwanted outcomes in CYP3A5 nonexpressers with an unexplained correlation with MDR1 C3435T polymorphisms.
Recommending routine pharmacogenetic testing of the individual SNPs in renal transplant patients is not yet feasible as the relationship of cost-effectiveness to ultimate impact on graft or patient survival must be justified by further prospective clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shilbayeh, Sirin. 2014. The impact of genetic polymorphisms on time required to attain the target tacrolimus levels and subsequent pharmacodynamic outcomes in pediatric kidney transplant patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 2, pp.266-277.
https://search.emarefa.net/detail/BIM-363037
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shilbayeh, Sirin. The impact of genetic polymorphisms on time required to attain the target tacrolimus levels and subsequent pharmacodynamic outcomes in pediatric kidney transplant patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 2 (Apr. 2014), pp.266-277.
https://search.emarefa.net/detail/BIM-363037
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shilbayeh, Sirin. The impact of genetic polymorphisms on time required to attain the target tacrolimus levels and subsequent pharmacodynamic outcomes in pediatric kidney transplant patients. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 2, pp.266-277.
https://search.emarefa.net/detail/BIM-363037
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 275-277
رقم السجل
BIM-363037
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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