Administration of anti-c-kit antibody into the cerebrospinal fluid leads to increased cell death in the developing cerebral cortex
المؤلفون المشاركون
Mashayikhi, Farhad
Gholizadeh, Lida
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 18، العدد 3 (30 سبتمبر/أيلول 2011)، ص ص. 261-266، 6ص.
الناشر
تاريخ النشر
2011-09-30
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
It is generally believed that during development, neurons are usually produced in excess.
Cell death occurs in the developing nervous system.
The survival of the developing neurons depends on many factors derived from the target sites, of which the neuronal trophic factors are by far the best known.
Stem cell factor (SCF) and its receptor, c-kit, is expressed in cells of nervous system during development and adulthood.
Although the role of SCF / c-kit in the nervous system is so far not clear, in vitro studies indicate that SCF / c-kit is trophic to certain neurons derived from neural crest and cerebral cortex.
In this study the effects of anti-c-kit antibody on cell death in the newborn chick cerebral cortex have been investigated.
Injection of anti-c-kit antibody into the cistern magnum increased the number of cell death and resulted in thinning of the cerebral cortex as compared to that from the control group.
It is concluded that SCF / c-kit is essential for cortical progenitor cell survival in the cerebral cortex.
Moreover, this method may be applied to the other factors and different CNS regions, allowing identification of factors involved in cell death.
It additionally re-emphasizes the importance of further investigations into the potential roles of SCF / c-kit signaling in neurodegenerative diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mashayikhi, Farhad& Gholizadeh, Lida. 2011. Administration of anti-c-kit antibody into the cerebrospinal fluid leads to increased cell death in the developing cerebral cortex. Saudi Journal of Biological Sciences،Vol. 18, no. 3, pp.261-266.
https://search.emarefa.net/detail/BIM-364364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mashayikhi, Farhad& Gholizadeh, Lida. Administration of anti-c-kit antibody into the cerebrospinal fluid leads to increased cell death in the developing cerebral cortex. Saudi Journal of Biological Sciences Vol. 18, no. 3 (2011), pp.261-266.
https://search.emarefa.net/detail/BIM-364364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mashayikhi, Farhad& Gholizadeh, Lida. Administration of anti-c-kit antibody into the cerebrospinal fluid leads to increased cell death in the developing cerebral cortex. Saudi Journal of Biological Sciences. 2011. Vol. 18, no. 3, pp.261-266.
https://search.emarefa.net/detail/BIM-364364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 265-266
رقم السجل
BIM-364364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر