Determination, revalidation, and development of artesunate analysis in different brands registered in Sudan
مقدم أطروحة جامعية
مشرف أطروحة جامعية
الجامعة
جامعة أم درمان الإسلامية
الكلية
كلية الصيدلة
القسم الأكاديمي
قسم الكيمياء الصيدلية
دولة الجامعة
السودان
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2011
الملخص الإنجليزي
-Purpose: The study was carried out to evaluate the quality of some artesunate tablets in retail and wholesale pharmacies in Sudan.
In particular, the study sought to ascertain the presence or otherwise of sub-standard and counterfeit artesunate tablets.
Method: The brands under study were selected based on frequency of prescription for the study.
The mechanical properties of the tablets were evaluated, namely: uniformity of weight, breaking strength, friability and rate of disintegration in aqueous medium,dissolution rate.
Spectrophotometric methods were used to determine the presence of artesunate and to assay the tablets.Similarlly, Titration standard method were used to confirm the results.
Result: None of the artesunate tablets sampled was found to be a counterfeit.
Most of the brands had acceptable mechanical properties in terms of mass uniformity, hardness, friability and disintegration time and dissolution rate% .
However, the artesunate content of the tablets was acceptable and all samples passed the International Pharmacopoeia content uniformity test according to titration standard method , similarlly all brands passed the proposed Spectrophotometric method except one namelly X4.
Conclusion: The excess weight of active ingredients could possibly precipitate overdosing or poisoning.And also The presence of poor quality artesunate tablets on the Sudanese market should alert drug regulatory authorities to be vigilant and continually monitor the quality of this life-saving drug.
Keywords: Artesunate tablets, Artemisinins, Spectrophotometric method, Counterfeit drugs, Compendial method.
التخصصات الرئيسية
الموضوعات
عدد الصفحات
61
قائمة المحتويات
Table of contents.
Abstract.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Analytical strategy.
Chapter Four : Materials and methods.
Chapter Five : Result, discussion and conclusion.
References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Faris, Fath al-Rahman. (2011). Determination, revalidation, and development of artesunate analysis in different brands registered in Sudan. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-364366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Faris, Fath al-Rahman. Determination, revalidation, and development of artesunate analysis in different brands registered in Sudan. (Master's theses Theses and Dissertations Master). Omdurman Islamic University. (2011).
https://search.emarefa.net/detail/BIM-364366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Faris, Fath al-Rahman. (2011). Determination, revalidation, and development of artesunate analysis in different brands registered in Sudan. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-364366
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-364366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
