Tamoxifen compared to best supportive care in advanced hepatocelluar carcinoma : a retrospective matched-cohort study
المؤلفون المشاركون
Zayn al-Din, Ahmad Abd al-Mabud
Id, Salim Muhammad
Darwish, Amirah Diya
Munir, Manar Muhammad
Sad al-Din, Muhammad
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 26، العدد 1 (31 مارس/آذار 2014)، ص ص. 1-7، 7ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2014-03-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Hepatocelluar carcinoma (HCC) is a common cancer worldwide as well as in Egypt with hepatitis B and C, alcohol and aflatoxins being the commonest risk factors.
Tamoxifen was initially reported to confer a marginal survival benefit in advanced HCC.
However, later reports declined any benefit.
Objective : To study the impact of tamoxifen on overall survival (OS) compared to best supportive care (BSC) in Egyptian patients with advanced HCC.
Methods : This retrospective matched-cohort study was conducted at Tanta Cancer Center (TCC), Egypt where 116 advanced HCC cases treated with tamoxifen were compared to TNM stage and Child-Pugh class matched 116 HCC cases who received BSC.
Results : The median OS in the tamoxifen group was 9.3 months (95 % confidence interval [CI], 6.7–11.9 months) compared to 8.7 months (95 %CI, 6.8–10.6) in the BSC group (p = 0.758).
With univariate analyses, it was shown that absence of fatigue, Child-Pugh class A, single tumors, less advanced tumors (T2), and absence of metastases (M0), had significantly better OS than their counterparts.
Multivariate analysis showed that absence of fatigue, Child-Pugh class A and T2 tumors were independent prognostic factors affecting OS.
Tamoxifen produced partial response and clinical stabilization in one % and 16 % of cases, respectively.
The median PFS with tamoxifen was 7.2 months (95 %CI, 5.2–9.5).
Conclusions : Tamoxifen did not show any OS advantage in Egyptian patients with advanced HCC.
Use of this drug is discouraged.
ª 2013 Production and hosting by Elsevier B.V.
on behalf of National Cancer Institute, Cairo University.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zayn al-Din, Ahmad Abd al-Mabud& Id, Salim Muhammad& Darwish, Amirah Diya& Munir, Manar Muhammad& Sad al-Din, Muhammad. 2014. Tamoxifen compared to best supportive care in advanced hepatocelluar carcinoma : a retrospective matched-cohort study. Journal of the Egyptian National Cancer Institute،Vol. 26, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-365167
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zayn al-Din, Ahmad Abd al-Mabud…[et al.]. Tamoxifen compared to best supportive care in advanced hepatocelluar carcinoma : a retrospective matched-cohort study. Journal of the Egyptian National Cancer Institute Vol. 26, no. 1 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-365167
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zayn al-Din, Ahmad Abd al-Mabud& Id, Salim Muhammad& Darwish, Amirah Diya& Munir, Manar Muhammad& Sad al-Din, Muhammad. Tamoxifen compared to best supportive care in advanced hepatocelluar carcinoma : a retrospective matched-cohort study. Journal of the Egyptian National Cancer Institute. 2014. Vol. 26, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-365167
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7
رقم السجل
BIM-365167
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر