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Basal cell hyperplasia (BCH) versus high grade prostatic intraepithelial neoplasia (HGPIN) in tiny prostatic needle biopsies : unusual diagnostic dilemma
المؤلفون المشاركون
Zaki, Muhammad
Yasin, Fatimah al-Zahra Salah al-Din
Muhammad, Iman M. S.
Salim, Muhammad Diya
Muhammad, Rabab Ahmad Ahmad
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 26، العدد 1 (31 مارس/آذار 2014)، ص ص. 15-22، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2014-03-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Histopathological differentiation between BCH and HGPIN in prostatic needle biopsies is a diagnostic challenge.
The gold standard for detection of HGPIN and BCH is histopathological examination ; however subjectivity in interpretation and tiny volume of obtained tissue hamper reliable diagnosis.
Aims : The aim of this study was to assess usefulness of using the p63 and p504s to solve this prob-lem.
Although the use of p63 and p504s is now well established in differentiation between preneo- plastic and neoplastic prostatic lesions, their usefulness in tiny tissue material is, however, not fully studied.
Methods : The study included a spectrum of 30 prostatic needle biopsies (5 BCH, 10 HGPIN, 10 indefinite luminal proliferations where BCH and HGPIN could not be distinguished from each other and 5 adenocarcinomas).
H&E stained sections were examined for histopathological features.
Other sections were stained immunohistochemically with p63 and p504s.
Results : The mean age of patients was 69 (SD = 7.6) years.
PSA range was 1.3–2.7 ng / ml.
Ultra-songraphic findings were unremarkable.
All BCH showed p504s / p63+ pattern, All HGPIN had p504s+ / p63+ pattern while carcinomas were p504s+ / p63.
After immunostaining combined with histopathological features; the 10 indefinite specimens could be diagnosed as 4 BCH and 6 HGPIN.
The article explains how applying this staining pattern on the challenging specimens, combined with histopathological features, can be helpful in proper identification of prostatic proliferations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yasin, Fatimah al-Zahra Salah al-Din& Muhammad, Iman M. S.& Zaki, Muhammad& Salim, Muhammad Diya& Muhammad, Rabab Ahmad Ahmad. 2014. Basal cell hyperplasia (BCH) versus high grade prostatic intraepithelial neoplasia (HGPIN) in tiny prostatic needle biopsies : unusual diagnostic dilemma. Journal of the Egyptian National Cancer Institute،Vol. 26, no. 1, pp.15-22.
https://search.emarefa.net/detail/BIM-365198
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yasin, Fatimah al-Zahra Salah al-Din…[et al.]. Basal cell hyperplasia (BCH) versus high grade prostatic intraepithelial neoplasia (HGPIN) in tiny prostatic needle biopsies : unusual diagnostic dilemma. Journal of the Egyptian National Cancer Institute Vol. 26, no. 1 (2014), pp.15-22.
https://search.emarefa.net/detail/BIM-365198
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yasin, Fatimah al-Zahra Salah al-Din& Muhammad, Iman M. S.& Zaki, Muhammad& Salim, Muhammad Diya& Muhammad, Rabab Ahmad Ahmad. Basal cell hyperplasia (BCH) versus high grade prostatic intraepithelial neoplasia (HGPIN) in tiny prostatic needle biopsies : unusual diagnostic dilemma. Journal of the Egyptian National Cancer Institute. 2014. Vol. 26, no. 1, pp.15-22.
https://search.emarefa.net/detail/BIM-365198
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 21-22
رقم السجل
BIM-365198
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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