Effects of smoking on lipid profile and homocysteine in coronary heart disease

الملخص EN

Smoking produces adverse effects on lipid profile and homocysteine, thus increasing the cardiovascular disease risk in coronary heart disease patients.

The present study was undertaken to evaluate plasma lipid profile, lipoprotein (a) and homocysteine in coronary heart disease of smoker male and female patients in two age groups ; below and above 50 years old, comparing them with nonsmokers healthy matched control.

Triglyceride plasma level (291.33 ± 101 mg / dl, mean ± SD, P value = 0.01) was elevated significantly in smoking coronary heart disease males less than 50 years old as compared to controls, while cholesterol (233.54 ± 44.9 mg / dl, P value = 0.02), LDL- cholesterol (174 ± 58.3 mg / dl, P value = 0.09), lipoprotein (a)- Lp(a) (65.06 ± 25.2 mg / dl, P value = 0.05), and triglycerides (188.18 ± 62.0 mg / dl, P value = 0.01) are significantly increased in males more than 50 years old.

No lipid profile parameter was significantly elevated in smoking coronary heart disease female less than 50 years old, while only homocysteine (28.83 ± 5.7 mg / dl, P value = 0.02) was elevated significantly in females more than 50 years.

In conclusion, smoking affects lipid profile and homocysteine and increases the cardiovascular disease risk among smokers.