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Evaluation of FcγRIIIB-NA1 NA2 polymorphism in visceral leishmaniasis
المؤلفون المشاركون
Lutfi, Pegah
Bazmani, Ahad
Matini, Muhammad
Hajilooi, Mehrdad
Abbasi, Muhammad
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 4 (30 إبريل/نيسان 2014)، ص ص. 1-4، 4ص.
الناشر
تاريخ النشر
2014-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Several lines of evidence demonstrating that innate and adaptive immunity play important roles in the defense against visceral leishmaniasis (VL).
A polymorphism within the FcγRIIIB gene can lead to the expression of three variants of NA1, NA2, and the combined one (NA1 / NA2) which alters affinity of IgG to its receptor.
Objectives : The main aim of this study was to evaluate the FcγRIIIB-NA1/NA2 polymorphism in the FcγRIIIB gene of VL patients in comparison to healthy controls.
Patients and Methods : In this cross-sectional study, three groups ; 54 seropositive patients with clinical presentation of VL (group 1), 104 seropositive patients without clinical presentation (group 2), and 104 healthy controls (group 3) were evaluated with respect to the FcγRIIIB-NA1 / NA2 polymorphism using a PCR-SSP method.
The titration of anti-leishmania antibodies was analyzed using an immunoflorescence technique.
Results : Our results indicated that polymorphisms within the FcγRIIIB gene (that lead to the expression of the NA1 / NA2 isoforms) are significantly associated with VL.
The results demonstrated that the genotype heterozygotic for FcγRIIIB-NA1 / NA2 expression was significantly increased in VL patients, group 1 when compared to groups 2 and 3.
Conversely, there is a decrease in homozygous NA1 and NA2 genotypes in VL patients ; however, the overall frequency of NA1 and NA2 alleles appear similar across the three cohorts examined.
Conclusions : According to our results, it is likely that the increased frequency of the FcγRIIIB-NA1 / NA2 genotype is associated with impaired immune responses against VL and its subsequent clearance from the patient.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abbasi, Muhammad& Lutfi, Pegah& Bazmani, Ahad& Matini, Muhammad& Hajilooi, Mehrdad. 2014. Evaluation of FcγRIIIB-NA1 NA2 polymorphism in visceral leishmaniasis. Iranian Red Crescent Medical Journal،Vol. 16, no. 4, pp.1-4.
https://search.emarefa.net/detail/BIM-366156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abbasi, Muhammad…[et al.]. Evaluation of FcγRIIIB-NA1 NA2 polymorphism in visceral leishmaniasis. Iranian Red Crescent Medical Journal Vol. 16, no. 4 (Apr. 2014), pp.1-4.
https://search.emarefa.net/detail/BIM-366156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abbasi, Muhammad& Lutfi, Pegah& Bazmani, Ahad& Matini, Muhammad& Hajilooi, Mehrdad. Evaluation of FcγRIIIB-NA1 NA2 polymorphism in visceral leishmaniasis. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 4, pp.1-4.
https://search.emarefa.net/detail/BIM-366156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4
رقم السجل
BIM-366156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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