Evaluation of FcγRIIIB-NA1 NA2 polymorphism in visceral leishmaniasis
المؤلفون المشاركون
Lutfi, Pegah
Bazmani, Ahad
Matini, Muhammad
Hajilooi, Mehrdad
Abbasi, Muhammad
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 4 (30 إبريل/نيسان 2014)، ص ص. 1-4، 4ص.
الناشر
تاريخ النشر
2014-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Several lines of evidence demonstrating that innate and adaptive immunity play important roles in the defense against visceral leishmaniasis (VL).
A polymorphism within the FcγRIIIB gene can lead to the expression of three variants of NA1, NA2, and the combined one (NA1 / NA2) which alters affinity of IgG to its receptor.
Objectives : The main aim of this study was to evaluate the FcγRIIIB-NA1/NA2 polymorphism in the FcγRIIIB gene of VL patients in comparison to healthy controls.
Patients and Methods : In this cross-sectional study, three groups ; 54 seropositive patients with clinical presentation of VL (group 1), 104 seropositive patients without clinical presentation (group 2), and 104 healthy controls (group 3) were evaluated with respect to the FcγRIIIB-NA1 / NA2 polymorphism using a PCR-SSP method.
The titration of anti-leishmania antibodies was analyzed using an immunoflorescence technique.
Results : Our results indicated that polymorphisms within the FcγRIIIB gene (that lead to the expression of the NA1 / NA2 isoforms) are significantly associated with VL.
The results demonstrated that the genotype heterozygotic for FcγRIIIB-NA1 / NA2 expression was significantly increased in VL patients, group 1 when compared to groups 2 and 3.
Conversely, there is a decrease in homozygous NA1 and NA2 genotypes in VL patients ; however, the overall frequency of NA1 and NA2 alleles appear similar across the three cohorts examined.
Conclusions : According to our results, it is likely that the increased frequency of the FcγRIIIB-NA1 / NA2 genotype is associated with impaired immune responses against VL and its subsequent clearance from the patient.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abbasi, Muhammad& Lutfi, Pegah& Bazmani, Ahad& Matini, Muhammad& Hajilooi, Mehrdad. 2014. Evaluation of FcγRIIIB-NA1 NA2 polymorphism in visceral leishmaniasis. Iranian Red Crescent Medical Journal،Vol. 16, no. 4, pp.1-4.
https://search.emarefa.net/detail/BIM-366156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abbasi, Muhammad…[et al.]. Evaluation of FcγRIIIB-NA1 NA2 polymorphism in visceral leishmaniasis. Iranian Red Crescent Medical Journal Vol. 16, no. 4 (Apr. 2014), pp.1-4.
https://search.emarefa.net/detail/BIM-366156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abbasi, Muhammad& Lutfi, Pegah& Bazmani, Ahad& Matini, Muhammad& Hajilooi, Mehrdad. Evaluation of FcγRIIIB-NA1 NA2 polymorphism in visceral leishmaniasis. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 4, pp.1-4.
https://search.emarefa.net/detail/BIM-366156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4
رقم السجل
BIM-366156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر