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Frequency of mutant p53 among acute lymphoblastic leukemia patients in Basrah, Iraq
المؤلفون المشاركون
Ibrahim, W. N.
Husni, H. J.
Hasan, J. G.
المصدر
العدد
المجلد 21، العدد 1 (30 يونيو/حزيران 2012)، ص ص. 35-38، 4ص.
الناشر
تاريخ النشر
2012-06-30
دولة النشر
قطر
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
study was carried out to investigate the status of p53 proteins and their relation to the occurrence of TEL-AML-1 translocation in children with acute lymphoblastic leukemia (ALL) attending the oncology unit at Basrah maternity and children hospital during the period from May 2009 to April 2010.
A total of 100 blood samples were collected from 40 newly diagnosed ALL cases, and 60 healthy children served as controls.
Anti-p53 antibody was detected by an enzyme-linked immunosorbent assay (ELISA), and TEL-AML-1 fusion gene was determined by reversetranscriptase polymerase reaction (RT-PCR) on RNA extracted from fresh blood samples.
The overall proportion of anti-p53 was 20% in the leukemic patients, whereas none of the healthy control group showed anti-p53 positivity.
This difference was statistically significant (P<0.05).
According to the French-American-British (FAB) classification, 75% of the anti-p53 positive cases were classified as L2 stage ALL.
There was a significant difference (P<0.05) between standard and high-risk groups of ALL patients in the frequency of anti-p53: 40% of high-risk group members had anti-p53 compared to 8% in the standard risk patients.
There was no association (P>0.05) between TEL-AML-1 translocation and anti-p53.
None of the standard risk patients with positive TEL-AML-1 fusion gene displayed the anti-p53 while 33.3% of TEL-AML-1 positive with high risk displayed the antip53 antibody.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, W. N.& Husni, H. J.& Hasan, J. G.. 2012. Frequency of mutant p53 among acute lymphoblastic leukemia patients in Basrah, Iraq. Qatar Medical Journal،Vol. 21, no. 1, pp.35-38.
https://search.emarefa.net/detail/BIM-366208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Husni, H. J.…[et al.]. Frequency of mutant p53 among acute lymphoblastic leukemia patients in Basrah, Iraq. Qatar Medical Journal Vol. 21, no. 1 (Jun. 2012), pp.35-38.
https://search.emarefa.net/detail/BIM-366208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, W. N.& Husni, H. J.& Hasan, J. G.. Frequency of mutant p53 among acute lymphoblastic leukemia patients in Basrah, Iraq. Qatar Medical Journal. 2012. Vol. 21, no. 1, pp.35-38.
https://search.emarefa.net/detail/BIM-366208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 38
رقم السجل
BIM-366208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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