Stress : depression et immunite anti-tumorale

الملخص FRE

The psychoneuroimmunology, a new concept, allow studying the link between immune and psychiatric factors on oncology.

In fact, the chronic stress and depression damage the immune reaction and contribute on the development and progression of cancer.

The persistent activation of the hypothalamic-pituitary-adrenal axis is found in many animal and human studies and could explain the link between immune and psychiatric factors.

Cellular and humoral factors are both implicated; cellular factors as the increased cytotoxic NK activity, the increased proliferative responses of lymphocytes; and humorals factors as increased production of cytokines : IL1, IL6, and TNFα.

A reciprocal relationship between immune and psychiatric factors offer a new therapeutic opportunity; group psychotherapy, hypnotherapy; might improve the immune system; and so that on cancer progression.

Key words: cancer, depression, immunity, stress.