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Clinicopathologic spectrum of crescentic glomerulonephritis : a hospital-based study
المؤلفون المشاركون
Usha, N. I.
Singh, Rana Gopal
Singh, Shivendra
Choudhury, Tauhidul Alam
Singh, Takhellambam Brojen
Rathore, Surendra Singh
Prabhakar
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 25، العدد 3 (30 يونيو/حزيران 2014)، ص ص. 689-696، 8ص.
الناشر
تاريخ النشر
2014-06-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Recent data regarding the clinical and histopathologic spectrum of crescentic glomerulonephritis (CSGN) among the Indian adult population is unknown.
Our aim is to study the clinicopathological features and outcome of CSGN.
It is a retrospective observational study from a tertiary care hospital in India over 3.5 years.
Biopsy-proven cases of CSGN (i.e., > 50 % crescents in glomeruli) were included in the study.
Cases with insufficient data were excluded.
There were 34 cases of CSGN, accounting for an incidence of 5.5 % among kidney biopsies.
The mean age was 32.2 ± 16.09 years, with male to female ratio of 12:22.
Clinical presentations of CSGN include rapidly progressive glomerulonephritis in 23 (67.7 %), chronic renal failure (CRF) in seven (20.5 %), nephrotic syndrome in two (5.8 %) and acute nephritic syndrome in two (5.8 %) patients.
The immunological profile of CSGN showed MPO-ANCA in nine (26.4 %), PR3-ANCA in one (2.9 %), both PR3 and MPO-ANCA in one (2.9 %), anti-GBM antibody in five (14.7 %) and lupus nephritis in six (17.6 %) patients.
All the three antibodies were present in one patient.
The percentage of glomeruli showing crescents were 100 % in nine (26.4 %) and ≥ 80 % in seven (20.5 %) patients.
Type of crescents seen were cellular in 11 (32.3 %) and fibrocellular in 22 (64.7 %) patients and fibrous in one (2.9 %) patient.
Interstitial fibrosis was found in seven (20.5 %) patients.
Dialysis dependency was seen in 11 (32.3 %) patients.
After 3 months of follow-up, mortality was seen in three (8.8 %), remission in eight (23.5 %), CRF in 15 (44.1 %) and ESRD in five (14.7 %) patients.
CSGN carries a poor prognosis.
The disorder may have an insidious onset and a slowly progressive course.
ANCA, anti-GBM-antibody and anti-dsDNA can coexist in CSGN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choudhury, Tauhidul Alam& Singh, Rana Gopal& Usha, N. I.& Singh, Shivendra& Singh, Takhellambam Brojen& Rathore, Surendra Singh…[et al.]. 2014. Clinicopathologic spectrum of crescentic glomerulonephritis : a hospital-based study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 3, pp.689-696.
https://search.emarefa.net/detail/BIM-371190
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choudhury, Tauhidul Alam…[et al.]. Clinicopathologic spectrum of crescentic glomerulonephritis : a hospital-based study. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 3 (2014), pp.689-696.
https://search.emarefa.net/detail/BIM-371190
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choudhury, Tauhidul Alam& Singh, Rana Gopal& Usha, N. I.& Singh, Shivendra& Singh, Takhellambam Brojen& Rathore, Surendra Singh…[et al.]. Clinicopathologic spectrum of crescentic glomerulonephritis : a hospital-based study. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 3, pp.689-696.
https://search.emarefa.net/detail/BIM-371190
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 695-696
رقم السجل
BIM-371190
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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