Antibacterial activities secondary metabolites from endophytic fungus Fusarium solani

الملخص EN

An endophytic fungus isolated from root of tomato plantdisplayed considerable antibacterial activity.

The fungus was identified as Fusarium solani based on morphological characterization.

Fungal extraction was carried out by ethyl acetate solvent.

The metabolite showed activity against both bacterial testes.

Bioactivity of fungal extract against E.

coli (ATCC25922) and S.

aureus (NCTC6571)by using a disc diffusion technique was examined.

The inhibition zones exhibited by fungal extract were 28 mm diam of E.

coli and 45 mm diam of S.

aureus.

MIC test revealed that the extract of Fusarium solani exhibited a minimal inhibition values (12.5 and 6.25 ug / L) against E.

coli and S.

aureus, respectively.

A verification of non-toxicity of the fungal extract against human blood revealed a negative test.

The chemical analysis of the fungal crude extract showed that extract ofF.

solani contains Tannins group and phenol compounds, absent amino acid and flavonoide.

The metabolite produced by the endophytic fungus could be an alternative source of antimicrobial agents against clinical pathogens.