Acute toxicity study of new dapsone schiff base derivative in laboratory rats

الملخص EN

Dapsone (4, 4-diaminodiphenylsulphon) is one of the types of sulfa drugs as an anti bacterial and is used particularly in the treatment of leprosy.

The aim of present study to investigate in vivo toxic effect and find acute toxic doses (LD50) of new dapsone Schiff base derivative compound (4-{[ 4(ethylideneamino)phenyl] sulfonyl} aniline, was evaluated in this study.

The experiment was performed on 10-14-week old male and female albino rats (225 ± 25 g) at the time of treatment.

Its acute toxic dose being 0.58 g.