Modifying cyclosporine associated renal allograft dysfunction
المؤلفون المشاركون
Vanikar, Aruna V.
Trivedi, Hargovind L.
Patel, R. D.
Mohapatra, N.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 20، العدد 5 (31 أكتوبر/تشرين الأول 2009)، ص ص. 770-774، 5ص.
الناشر
تاريخ النشر
2009-10-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Transplantation is accepted therapy for chronic kidney disease.
However the essential immunosuppressive agents for graft survival have their own side-effects.
Renal biopsy is a reliable tool for diagnosing cyclosporine (CsA) nephrotoxicity.
To present our observations on CsA toxicity in renal allograft biopsies, we studied prospectively 207 renal allograft biopsies performed for graft dysfunction as per Ahmedabad Tolerance Induction Protocol (ATIP) and compared them to 50 controls from January to October 2007.
The ATIP comprised donor specific leucocyte infusions, low dose target specific irradiation; non-myeloablative conditioning with Anti-T ± B cell antibodies followed by intraportal administration of cultured donor bone marrow (BM) ± adipose tissue derived mesenchymal stem cells.
Renal transplantation was performed following negative lymphocytotoxicity cross-matching.
The post-transplant immunosuppressive agents included CsA 2.5 ± 0.5 mg/kg BW/day and prednisone 0.2 mg/kg BW/day.
The controls were transplanted using standard triple immunosuppressive agents including CsA 5 ± 1 mg/Kg BW/day, prednisone 0.6 mg/kg BW/day, and MMF/ Azathioprine.
The Institutional Review Board approved the ATIP.
The biopsies were categorized into 2 groups; group A (N=97): performed < 6 months, group B (N= 160), > 6 months posttransplant.
Acute CsA toxicity was observed in group A: 2.5% ATIP and 11.1% controls; group B: 16.2% ATIP and 8.8% controls.
Chronic CsA toxicity was observed in group B: 10.8 % ATIP and 17.6 % controls.
Acute toxicity was more in the ATIP, while chronic toxicity was more in the controls.
CsA doses were reduced post-biopsy and resulted in improved graft function evaluated by serum creatinine.
We conclude that CsA nephrotoxicity evaluated by allograft biopsy resulted in allograft function recovery by decreasing the cyclosporine dose, and the ATIP decreased the incidence of CsA nephrotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohapatra, N.& Vanikar, Aruna V.& Patel, R. D.& Trivedi, Hargovind L.. 2009. Modifying cyclosporine associated renal allograft dysfunction. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 5, pp.770-774.
https://search.emarefa.net/detail/BIM-37383
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohapatra, N.…[et al.]. Modifying cyclosporine associated renal allograft dysfunction. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 5 (Oct. 2009), pp.770-774.
https://search.emarefa.net/detail/BIM-37383
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohapatra, N.& Vanikar, Aruna V.& Patel, R. D.& Trivedi, Hargovind L.. Modifying cyclosporine associated renal allograft dysfunction. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 5, pp.770-774.
https://search.emarefa.net/detail/BIM-37383
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 774.
رقم السجل
BIM-37383
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر