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Leptin, insulin like growth factor-1 and thyroid profile In a studied sample of Egyptian children with down Syndrome
المؤلفون المشاركون
al-Jabali, Huwayda Husni
Zaki, Iman Ahmad
Muhammad, Inas Zakariyya
Ajwah, Sarah Hasan
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 15، العدد 2 (30 إبريل/نيسان 2014)، ص ص. 131-138، 8ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2014-04-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Several mechanisms have been suggested for obesity in Down syndrome.
Aim of the study : Assessment of serum levels of leptin, insulin like growth factor-I (IGF-I), thyroid stimulating hormone (TSH) and free thyroxin (FT4) in a prepubertal Egyptian sample of children with DS compared to their age and sex matched healthy controls and sibs of some of them.
Subjects and methods : A prospective case control study was conducted on 80 children, classified as follows : Groups I & II : enrolled 20 cases with DS for each, sibs were studied only for group I, Group III : 20 healthy siblings of group I, and Group IV : 20 healthy controls.
Anthropometric measurements, serum leptin, IGF-1, TSH, and FT4 assessment using enzyme linked immuno-sorbent assay (ELISA) were carried out for all studied children.
Results : DS children whether with studied sibs or without studied sibs had significantly higher mean values of leptin levels compared to sibs of group I & IV (P = 0.0001 for all).
Meanwhile, mean values of IGF-I showed statistically insignificant differences between all studied groups (p > 0.05 for all).
Studied DS children whether with studied sibs or without studied sibs had significantly higher mean values of TSH levels compared to sibs of group I and controls (P = 0.0001 for all).
Mean values of FT4 were significantly higher in enrolled DS without their studied sibs compared to sibs of group I (p = 0.01), while mean values of FT4 were significantly lower in sibs of group I compared to controls (p = 0.001).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Jabali, Huwayda Husni& Zaki, Iman Ahmad& Ajwah, Sarah Hasan& Muhammad, Inas Zakariyya. 2014. Leptin, insulin like growth factor-1 and thyroid profile In a studied sample of Egyptian children with down Syndrome. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 2, pp.131-138.
https://search.emarefa.net/detail/BIM-374321
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ajwah, Sarah Hasan…[et al.]. Leptin, insulin like growth factor-1 and thyroid profile In a studied sample of Egyptian children with down Syndrome. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 2 (Apr. 2014), pp.131-138.
https://search.emarefa.net/detail/BIM-374321
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Jabali, Huwayda Husni& Zaki, Iman Ahmad& Ajwah, Sarah Hasan& Muhammad, Inas Zakariyya. Leptin, insulin like growth factor-1 and thyroid profile In a studied sample of Egyptian children with down Syndrome. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 2, pp.131-138.
https://search.emarefa.net/detail/BIM-374321
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 137-138
رقم السجل
BIM-374321
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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