C-reactive protien, a valuable predictive marker in chronic kidney diseases
المؤلفون المشاركون
Ibrahim, Georgi
Lesley, Nansi
Sundaram, Varun
Sundaram, Vivek
Mathew, Milly
Sathiah, Vijiaboobbathi
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 20، العدد 5 (31 أكتوبر/تشرين الأول 2009)، ص ص. 811-815، 5ص.
الناشر
تاريخ النشر
2009-10-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
The aim of this study was to look for correlation between the markers for malnutrition and inflammation, and atherosclerosis in pre-dialysis chronic kidney disease (CKD) patients.
This observational study involved 100 pre dialysis patients (age 57 ± 12 years) from the out-patient and in-patient departments over a span of two years.
Informed consent was obtained from all the study patients.
Highly sensitive C-reactive protein (hsCRP) was assayed as a marker of chronic inflammation.
Nutritional status was assessed using serum albumin and body mass index (BMI).
Clinical and laboratory data were collected and a carotid doppler study was performed using duplex ultrasonography method to look for carotid artery stenosis.
Renal function was assessed by calculating the estimated glomerular filtration rate (GFR) by the MDRD-2 formula.
These data were later analyzed using descriptive statistics, Chi-square test and the students' t test.
The mean GFR was 28.3 ± 16.4 mL/min/1.73m 2 .
The mean value of CRP was 14.3 ± 11.4 mg /L.
Sixty-seven percent of patients had elevated CRP (> 6 mg/L) levels.
Patients with higher CRP levels showed lower mean serum albumin levels (3.2 ± 0.7 gm/dL) (P < 0.01).
Only three patients had evidence of hemodynamically significant carotid disease (lumen diameter < 50%) with no statistical significance.
Low serum albumin levels were associated with low hemoglobin levels (< 10 gm/dL), low GFR and presence of diabetes mellitus.
Our results indicate that a high degree of inflammation and malnutrition exists in pre-dialysis patients as seen by high CRP values and low serum albumin levels.
Synergism of these factors could contribute to atherosclerosis in CKD apart from the classic risk factors.
To our knowledge, this is the first study, which has compared these markers of inflammation in pre-dialysis patients in developing countries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Georgi& Sundaram, Varun& Sundaram, Vivek& Mathew, Milly& Lesley, Nansi& Sathiah, Vijiaboobbathi. 2009. C-reactive protien, a valuable predictive marker in chronic kidney diseases. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 5, pp.811-815.
https://search.emarefa.net/detail/BIM-37460
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Georgi…[et al.]. C-reactive protien, a valuable predictive marker in chronic kidney diseases. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 5 (Oct. 2009), pp.811-815.
https://search.emarefa.net/detail/BIM-37460
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Georgi& Sundaram, Varun& Sundaram, Vivek& Mathew, Milly& Lesley, Nansi& Sathiah, Vijiaboobbathi. C-reactive protien, a valuable predictive marker in chronic kidney diseases. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 5, pp.811-815.
https://search.emarefa.net/detail/BIM-37460
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 814-815.
رقم السجل
BIM-37460
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر