Growth in infants with congenital adrenal hyperplasia due to 21-hydroxylase deficiency an analysis of the factors affecting height
المؤلفون المشاركون
Ibrahim, Amani
Hasan, Muna Mamduh
Abd al-Salam, Aminah
Huthail, Hamsah
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 61، العدد 2 (30 يونيو/حزيران 2013)، ص ص. 57-62، 6ص.
الناشر
تاريخ النشر
2013-06-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: It has been suggested that overtreatment of infants with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency might affect their growth and final height.
Objective: To assess the axiological parameters of infants with CAH due to 21-hydroxylase deficiency from their first presentation in neonatal period and during infancy, in an attempt to decide the optimum doses of glucocorticoid, mineralocorticoid and salt therapy that can achieve androgen suppression, prevent life-threatening salt-wasting crises, and allow normal growth velocity for age.
Materials and methods: Retrospective study conducted in the Diabetes Endocrine and Metabolism Pediatric Unit at Children’s Hospital, Cairo University included baseline and follow-up data of 28 infants with 21-hydroxylase deficiency.
Results: Median age at presentation was 34 days.
Lower doses of hydrocortisone (<20 mg/m2/ day) were associated with better growth, not reaching a statistical significance.
Delta change in length standard deviation score (SDS) was significantly higher in males (p= 0.01).
Delta change in length and weight SDS of cases with mean basal length SDS below 2 were significantly higher than those with mean basal length SDS above 2 (p= 0.02 and 0.04 respectively).
No correlations were found between delta height-SDS and age at diagnosis, duration of follow-up, glucocrticoid or mineralocorticoid dosing.
Conclusion: Poor growth in infants with salt wasting CAH was not related to age at diagnosis and start of therapy, doses of glucocorticoid, fludrocortisones, or saline therapy.
Male sex and mean basal length SDS below 2 were associated with a more favorable growth catch up.
Further prospective studies with inclusion of intercurrent illnesses and nutritional status are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hasan, Muna Mamduh& Ibrahim, Amani& Abd al-Salam, Aminah& Huthail, Hamsah. 2013. Growth in infants with congenital adrenal hyperplasia due to 21-hydroxylase deficiency an analysis of the factors affecting height. Egyptian Pediatric Association Gazette،Vol. 61, no. 2, pp.57-62.
https://search.emarefa.net/detail/BIM-374673
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hasan, Muna Mamduh…[et al.]. Growth in infants with congenital adrenal hyperplasia due to 21-hydroxylase deficiency an analysis of the factors affecting height. Egyptian Pediatric Association Gazette Vol. 61, no. 2 (Jun. 2013), pp.57-62.
https://search.emarefa.net/detail/BIM-374673
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hasan, Muna Mamduh& Ibrahim, Amani& Abd al-Salam, Aminah& Huthail, Hamsah. Growth in infants with congenital adrenal hyperplasia due to 21-hydroxylase deficiency an analysis of the factors affecting height. Egyptian Pediatric Association Gazette. 2013. Vol. 61, no. 2, pp.57-62.
https://search.emarefa.net/detail/BIM-374673
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 62
رقم السجل
BIM-374673
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر