Preoperative alterations of interleukin-6 levels during surgical removal of impacted lower third molar

الملخص EN

The aim of the study is to assess the blood levels of (interleukin-6) at different intervals of time after surgical removal of impacted lower third molars.

Materials and Methods : The study group comprised 26 patients with impacted lower third molars .All extractions were performed under local anaesthesia using the inferior alveolar nerve block together with vestibular infiltration.

A buccal full thickness two sided mucoperiosteal flap was raised.

Sterile low-speed straight hand pieces and sterile distilled water were used for ostectomy.

After tooth removal the wound was closed with 3-0 black silk suture.

Three blood samples were drawn from each patient; one before the operation, the second 2hr.

post operation and the third 24hr.

post operation.

The blood samples were collected through venipunc-ture, serum separated and stored in at -20ºC.

Analysis was performed using the Enzyme linked Im-munosourbant assay (ELISA).

Results : The level of IL-6, in this study, showed an increase following surgery, in comparison with the level before operation.

This increase in the level of Interleukin-6 re-mained high until 24hr after operation.

Conclusion : Interleukin-6 (IL-6) is higher after surgical extrac-tion of lower third molars and remained with high levels to 24hr.

after operation.