Histopathological study on the effect of dietary contamination with fumonisin b1 on liver, kidney, lung and brain of new zealand rabbits

الملخص EN

he present study demonstrated the effect of dietary contamination with fumonisin B1 (a mycotoxin mainly exist in corn seeds) in three doses (5, 25, 125 ppm) for two weeks on the histological pattern of liver, kidney, lung and brain of New Zealand rabbits.

In 5 and 25 ppm treated rabbits, the liver revealed moderate lymphocytic infiltration and hepatic nuclear pyknosis.

The kidney showed degeneration of the glomerular tufts and signs of necrosis in the epithelial cells lining of the cortical tubules.

In lung, the alveoli walls were congested with RBCs and lymphocytic cells and the alveoli were full of pink materials.

In brain tissues, the granular layer had large vacuoles and clear separation between different layers of the cerebral cortex was recorded.

In 125 ppm treated rabbits, the hepatic tissues lost their normal architecture and showed increased lymphocytic aggregation and necrosis.

The kidney showed severe degree of tubular epithelial damage and disruption of the Bowman's capsules.

The lung showed a sheet of neutrophils (early abscess pneumonia) and the alveolar walls were not clearly seen.

The brain revealed numerous pyknotic neurons, increased number of vacuoles and increased separation between layers of the cerebral cortex.

The results indicated serious dose dependent histological alterations in liver, brain, lung and kidney of rabbits fed on diets contaminated with fumonisin B1.

Such alterations could indicate a disturbance in the functional activity of these organs as a result of fumonisin toxicity.