Effect of lisinopril versus amlodipine on QTc dispersion patients with stage I hypertension

الملخص EN

QT dispersion is the difference between maximum QT and minimum QT across the 12 ECG leads, it represent ventricular repolarization variability and cardiovascular risk outcome stratification.

Aim : To clarify the difference between lisinopril and amlodipine as anti-hypertensive drugs on QTc dispersion and thus the cardiovascular risk outcome stratification.

Patients and Methods : A 50 patients consulted the private clinic with newly diagnosed stage I hypertension [ systolic BP = 140-159 mm ⁄ Hg and or diastolic BP = 90-99 mm ⁄ Hg], 25 were males and 25 females with age mean was 38 years and body weight mean was 81 Kg.

Patients were randomly divided into 2 groups, each group contained 25 patients.

Group I received lisinopril 10 mg daily as a single dose, group II received amlodipine 5 mg daily as a single dose.

Treatment continued for 12 weeks and at the end of the study, a 12 leads ECG was done for each patient and QTc dispersion was examined by measuring the difference between maximum and minimum QT interval and QT correction.

Results : Calculation of QTcD for both lisinopril and Amlodipine treated group was-0.030 and -0.032 respectively with no significant difference [P > 0.05].

Conclusion : This study showed no significant difference between lisinopril and amlodipine in affecting QT dispersion among patients with stage I hypertension.