Ovarian surface epithelium receptors during pregnancy and estrus cycle of rats with emphasis on steroids and gonadotropin fluctuation
المؤلف
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 21، العدد 3 (31 يوليو/تموز 2014)، ص ص. 232-237، 6ص.
الناشر
تاريخ النشر
2014-07-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
The present study is designed to demonstrate the ovarian surface epithelial cells’ (OSE) estrogen receptor a (ERa) and progesterone receptor (PR) during pregnancy and estrous cycle in rat.
Moreover, determination of the levels of plasma progesterone, estradiol, FSH and LH was also made.
The levels of plasma progesterone, estradiol, FSH and LH concentrations were determined on days 7 (n = 5), 14 (n = 5), and 21 (n = 5) of pregnancy in three groups of rats and during the estrous cycle (n = 5) using an ELISA kit.
Immunohistochemical method for PR and ERa expressions was also made on the ovary.
During pregnancy, FSH and LH remained low except at term when LH levels began to increase from 16 ng / ml to 47 ng / ml.
Progesterone levels significantly exceeded estradiol values in all pregnant rats with a peak value of 202 ng / ml on day 14.
Elevated progesterone levels were associated negatively with LH and estradiol levels during pregnancy.
The levels of estradiol surged significantly on day 21.
Immunohistochemistry of the ovary showed low levels of OSE cells staining positive for ERa expression.
ERa positive cells were absent on day 7 and 14 of pregnancy, only day 21 recorded a very low percentage of immunostaining (0.5 %) within the nuclei of OSE cells.
On the contrary, immunostaining of PR was not observed within the nuclei of OSE cells in all groups of study.
In conclusion, these results may suggest that the progesterone effect during pregnancy seems to be overriding the positive effect of estrogens on OSE cells.
High progesterone levels may have a direct negative effect on gonadotropin production and thereby it might inhibit events leading to both follicular development and OSE proliferation.
Understanding the factors affecting OSE proliferation may help elucidating the mechanism (s) of assisted diseases such as ovarian cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saddick, Salina Y.. 2014. Ovarian surface epithelium receptors during pregnancy and estrus cycle of rats with emphasis on steroids and gonadotropin fluctuation. Saudi Journal of Biological Sciences،Vol. 21, no. 3, pp.232-237.
https://search.emarefa.net/detail/BIM-380171
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saddick, Salina Y.. Ovarian surface epithelium receptors during pregnancy and estrus cycle of rats with emphasis on steroids and gonadotropin fluctuation. Saudi Journal of Biological Sciences Vol. 21, no. 3 (2014), pp.232-237.
https://search.emarefa.net/detail/BIM-380171
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saddick, Salina Y.. Ovarian surface epithelium receptors during pregnancy and estrus cycle of rats with emphasis on steroids and gonadotropin fluctuation. Saudi Journal of Biological Sciences. 2014. Vol. 21, no. 3, pp.232-237.
https://search.emarefa.net/detail/BIM-380171
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 236-237
رقم السجل
BIM-380171
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر