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Detection and genotyping of human papilloma virus-associated oral lichen planus by in situ hybridization technique
المؤلف
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 51، العدد 3 (30 سبتمبر/أيلول 2009)، ص ص. 276-282، 7ص.
الناشر
تاريخ النشر
2009-09-30
دولة النشر
العراق
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Molecular DNA hybridization has confirmed more than 120 different human papilloma virus (HPV) genotypes.
A small group of them have high- risk oncogenic potential.
Many studies have described an association of such high risk-HPV genotypes with a variety of oral lesions including squamous cell carcinoma, leukoplakia, and lichen planus.
.
Materials and Methods : A total number of 42 tissue specimens, representing 27 patients with oral lichen planus and 15 apparently-healthy oral tissues, were included in this study.
The molecular methods for HPV detection and genotyping were performed by in situ hybridization(ISH) using cocktailed- and specific high- risk HPV DNA probes, respectively.
Results : The overall percentage of HPV in the total group of patients with oral lichen planus (OLP) was 33.3 %.
Negative HPV DNA- ISH reactions were detected in all tissues of the control group.
The overall genotyping results revealed HPV 16- DNA in all HPV- positive oral lichen planus tissues , while none of these OLP tissues showed ISH reactions for HPV 18-DNA or HPV 31/33- DNA.
Conclusions: The significant incidence of such high oncogenic HPV genotype in those patients with oral precancerous lesions could have a relevant importance along its pathogenesis and the multisteps oral carcinogenesis , HPV-16-associated oral lichen planus that has mostly previliged the site of cheek mucosa represents a herald indicator for spread of such sexually important transmitted infection among Iraqi general population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Sad H. Muhammad. 2009. Detection and genotyping of human papilloma virus-associated oral lichen planus by in situ hybridization technique. Journal of the Faculty of Medicine Baghdad،Vol. 51, no. 3, pp.276-282.
https://search.emarefa.net/detail/BIM-380438
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Sad H. Muhammad. Detection and genotyping of human papilloma virus-associated oral lichen planus by in situ hybridization technique. Journal of the Faculty of Medicine Baghdad Vol. 51, no. 3 (2009), pp.276-282.
https://search.emarefa.net/detail/BIM-380438
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Sad H. Muhammad. Detection and genotyping of human papilloma virus-associated oral lichen planus by in situ hybridization technique. Journal of the Faculty of Medicine Baghdad. 2009. Vol. 51, no. 3, pp.276-282.
https://search.emarefa.net/detail/BIM-380438
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 281-282
رقم السجل
BIM-380438
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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