Increased frequency of complement C4 "null" alleles in autoimmune hepatitis

الملخص EN

Background : Human leukocyte antigen (HLA) is the most polymorphic genetic system in man.

The genes of this region influence susceptibility to certain diseases.

Patients and methods : Immunofixation test is the method used to asses C4 polymorphism of 100 blood samples of 60 AIH patients and 40 healthy normal controls.

Results : An increased frequency of C4A*Q0 was observed for patients group versus control group with P-value (0.003).

Conclusions : This finding demonstrated that C4A*Q0 might play a role in AIH susceptibility.