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Procaspase-3 status in benign prostatic hyperplasia and carcinoma : a correlative retrospective study
المؤلفون المشاركون
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 51، العدد 3 (30 سبتمبر/أيلول 2009)، ص ص. 316-319، 4ص.
الناشر
تاريخ النشر
2009-09-30
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Benign prostatic hyperplasia and prostatic adenocarcinoma are two of the most common pathologic mass lesions.
Both are encountered mainly in elderly males.
The caspases family is a group of at least 15 known proteases that serve as initiator & effector molecules of the apoptosis pathway.
Caspase-3, in particular, is thought to play a pathogenetic role in both prostatic hyperplasia and carcinoma.
Finasteride is a medication that has routinely been given to patients with hyperplasia and carcinoma; its prostate size-reducing effect is thought to be mediated through caspases.
Patients and methods: fifty patients with prostatic mass lesions were included in this study (20 with hyperplasia & 30 with adenocarcinoma); all were on finasteride treatment.
The carcinoma cases were graded according to Gleason scoring system.
All cases were analyzed for procaspase-3 strength of staining.
Results: benign hyperplasia & well-differentiated carcinomas show high expression of procaspase-3, in contrast loss of expression of this marker was noted in moderately & poorly differentiated carcinomas.
Conclusion: there is a strong statistical correlation between caspase-3 expression and the degree of tumor differentiation.
This may allow the utilization of this marker as a potential prognostic factor, especially in limited biopsy samples.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qadir, Ala A.& Rashid, Nabil W.. 2009. Procaspase-3 status in benign prostatic hyperplasia and carcinoma : a correlative retrospective study. Journal of the Faculty of Medicine Baghdad،Vol. 51, no. 3, pp.316-319.
https://search.emarefa.net/detail/BIM-380475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qadir, Ala A.& Rashid, Nabil W.. Procaspase-3 status in benign prostatic hyperplasia and carcinoma : a correlative retrospective study. Journal of the Faculty of Medicine Baghdad Vol. 51, no. 3 (2009), pp.316-319.
https://search.emarefa.net/detail/BIM-380475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qadir, Ala A.& Rashid, Nabil W.. Procaspase-3 status in benign prostatic hyperplasia and carcinoma : a correlative retrospective study. Journal of the Faculty of Medicine Baghdad. 2009. Vol. 51, no. 3, pp.316-319.
https://search.emarefa.net/detail/BIM-380475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 319
رقم السجل
BIM-380475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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