Clinical utility of b-type natriuretic peptides in patients with heart failure and renal dysfunction
المؤلفون المشاركون
Tawfiq, Jamal A.
Khalil, Fawzi A.
Hasan, Amani M.
al-Shabrawi, Maha M.
المصدر
Suez Canal University Medical Journal
العدد
المجلد 16، العدد 1 (30 يونيو/حزيران 2013)، ص ص. 69-77، 9ص.
الناشر
تاريخ النشر
2013-06-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Increased plasma level of B-type Natriuretic peptide (BNP) in chronic kidney disease (CKD) and hemodialysis patients with volume overload and heart failure (HF) is common and de-creases during dialysis.
BNP and N-terminal pro-hormone B-type Natriuretic peptide (NT-proBNP) are established HF markers, but the concomitant presence of CKD changes their interpretation in a significant manner.
Aim : to evaluate the effect of compromised kidney function on the level of BNP in Egyptian patients with CKD and ESRD.
Patients and Methods : from June 2011 to June 2012, forty-seven patients (17 CKD patients on regular follow up and 30 ESRD patients on regular hemo-dialysis) were tested for serum BNP and Echocardiography.
Normal range of BNP was calculated from 17 apparently healthy individuals (control group).
Results : Plasma BNP was significantly higher in both CKD patients and ESRD patients compared to controls (p < 0.001).
In CKD group, BNP values did not differ between patients with normal diastolic function and those with impaired di-astolic function (p = 0.57).
However, in ESRD patients, BNP was significantly higher in patients with impaired diastolic function compared to those with normal diastolic function (p = 0.018).
A positive correlation was found between diastolic dysfunction and BNP levels in CKD patients (r = 0.45 ; p = 0.013).
Our study could not prove that the BNP could provide a certain cutoff value to di-agnose ventricular function.
BNP value for diagnosis of left ventricle systolic dysfunction was set at > 37 pg / ml (p = 0.08).
While, BNP value for diagnosis of left ventricle diastolic dysfunction was set at > 39.1 pg / ml (p = 0.24).
Conclusion : BNP can be considered as a diagnostic and prognostic test for diagnosis of HF in CKD and ESRD patients.
High plasma level of BNP may indicate the need for further pharmacological treatment for HF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tawfiq, Jamal A.& Khalil, Fawzi A.& Hasan, Amani M.& al-Shabrawi, Maha M.. 2013. Clinical utility of b-type natriuretic peptides in patients with heart failure and renal dysfunction. Suez Canal University Medical Journal،Vol. 16, no. 1, pp.69-77.
https://search.emarefa.net/detail/BIM-380579
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khalil, Fawzi A.…[et al.]. Clinical utility of b-type natriuretic peptides in patients with heart failure and renal dysfunction. Suez Canal University Medical Journal Vol. 16, no. 1 (2013), pp.69-77.
https://search.emarefa.net/detail/BIM-380579
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tawfiq, Jamal A.& Khalil, Fawzi A.& Hasan, Amani M.& al-Shabrawi, Maha M.. Clinical utility of b-type natriuretic peptides in patients with heart failure and renal dysfunction. Suez Canal University Medical Journal. 2013. Vol. 16, no. 1, pp.69-77.
https://search.emarefa.net/detail/BIM-380579
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 76-77
رقم السجل
BIM-380579
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر