Clinical significance of serum vascular endothelial growth factor among hepatitis c cirrhotic patients with hepatocellular carcinoma and its correlation with tumor progression
المؤلفون المشاركون
Muhyi al-Din, Muhammad M.
Umar, Siham A.
Taj, Loaa A.
Sheded, Mahmud M.
المصدر
Suez Canal University Medical Journal
العدد
المجلد 14، العدد 2 (31 ديسمبر/كانون الأول 2011)، ص ص. 10-17، 8ص.
الناشر
تاريخ النشر
2011-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide.
HCC accounts for 85 % to 90 % of primary liver cancers.
Clearly, there is need for other markers to have high sensitivity in early diagnosis of HCC.
The elevation of vascular endo-thelial growth factor (VEGF) implies a promotion of tumor angiogenesis, with high predictive value in tumor progression and prognosis in various types of cancer.
Aim : the aim of this work was to study the clinical significance of serum VEGF in HCC patients and correlating it with tumor progression (tumor size and portal vein thrombosis).
Patients and Methods : This study was conducted at the internal medicine department of Suez Canal University hospitals on three groups of patients having chronic HCV, Group I, patients having liver cirrhosis without HCC, Group II, patients with HCC and single nodule, Group III, patients with HCC , single nodule with portal vein thrombosis.
Results : Alpha-fetoprotein level was significantly higher in HCC groups of patients (group II and III) than in non-HCC (group I).
Also, mean VEGF was significantly higher in HCC groups of patients than control group.
Among HCC groups of patients, the level of VEGF had high sensitivity, specificity (72.5 % and 100 %) and predictive value for diagnosis of HCC, with significant positive correlation between VEGF level and tumor progression (tumor size and venous invasion).
Conclusions : Serum level of VEGF in HCC patients had high sensitivity, specificity, and predictive value for diagnosis of HCC with significant positive correlating with tumor progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhyi al-Din, Muhammad M.& Umar, Siham A.& Taj, Loaa A.& Sheded, Mahmud M.. 2011. Clinical significance of serum vascular endothelial growth factor among hepatitis c cirrhotic patients with hepatocellular carcinoma and its correlation with tumor progression. Suez Canal University Medical Journal،Vol. 14, no. 2, pp.10-17.
https://search.emarefa.net/detail/BIM-380633
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhyi al-Din, Muhammad M.…[et al.]. Clinical significance of serum vascular endothelial growth factor among hepatitis c cirrhotic patients with hepatocellular carcinoma and its correlation with tumor progression. Suez Canal University Medical Journal Vol. 14, no. 2 (2011), pp.10-17.
https://search.emarefa.net/detail/BIM-380633
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhyi al-Din, Muhammad M.& Umar, Siham A.& Taj, Loaa A.& Sheded, Mahmud M.. Clinical significance of serum vascular endothelial growth factor among hepatitis c cirrhotic patients with hepatocellular carcinoma and its correlation with tumor progression. Suez Canal University Medical Journal. 2011. Vol. 14, no. 2, pp.10-17.
https://search.emarefa.net/detail/BIM-380633
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 15-17
رقم السجل
BIM-380633
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر