Interleukin-10 protects rat liver from CCl4-induced fibrogenesis via inhibition of hepatic stellate cells Ac-tivation
المؤلفون المشاركون
Abd al-Hamid, Ala al-Din Sad
Nasir al-Din, Wail A.
Kamil, Amr A.
Abd al-Rahman, Jamal M.
المصدر
Suez Canal University Medical Journal
العدد
المجلد 16، العدد 1 (30 يونيو/حزيران 2013)، ص ص. 37-44، 8ص.
الناشر
تاريخ النشر
2013-06-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : After liver injury, hepatic stellate cells (HSCs) lose vitamin A and transform into myofibroblasts (MFB), called activated HSCs, which express α-SMA and have the function of con-tractibility, proliferation, and fibrogenesis.
IL-10 is active as an antifibrogenic drug able to reduce the α-SMA expression in ongoing fibrogenesis.
Aim : To study the effect of interleukin-10 on the expression of α-smooth muscle actin (α-SMA), in hepatic stellate cells of experimental rats with hepatic fibrosis.
Materials and Methods : one hundred and eight rats were divided equally into two groups : control and CCl4-treated group, which subdivided into 3 subgroups, a group immediately puts into death after treatment, spontaneous recovery (SR) group, and IL-10-treated group.
Each group included 27 rats.
Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin were assessed.
Livers were taken out and processed for the expression of tissue α-smooth muscle actin (α-SMA) by immunohistochemical assay.
Results : serum ALT and AST were significantly higher in rats injected with CCl4 (90.01 ± 2.77 IU / L and 56.42 ± 3.27 IU / L, P < 0.05 each), moderately reduced in the SR group (58.26 ± 1.94 IU / L and 37.18 ± 2.31IU / L, P < 0.05 each), and significantly reduced by administration of IL-10 (28.77 ± 2.03IU / L and 37.18 ± 2.31 IU / L, p < 0.05 each).
The expression of α-SMA in the hepatic cells was strong in CCl4-induced fibrosis group compared to the control group (p < 0.05).
The expression was moderate in the spontaneous recovery group, but less than CCl4-treated group and was significantly reduced in IL-10-treated group.
Conclusions : IL-10 is an active antifibrogenic drug that reduces α-SMA expression in ongoing fibrogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nasir al-Din, Wail A.& Abd al-Rahman, Jamal M.& Abd al-Hamid, Ala al-Din Sad& Kamil, Amr A.. 2013. Interleukin-10 protects rat liver from CCl4-induced fibrogenesis via inhibition of hepatic stellate cells Ac-tivation. Suez Canal University Medical Journal،Vol. 16, no. 1, pp.37-44.
https://search.emarefa.net/detail/BIM-380643
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nasir al-Din, Wail A.…[et al.]. Interleukin-10 protects rat liver from CCl4-induced fibrogenesis via inhibition of hepatic stellate cells Ac-tivation. Suez Canal University Medical Journal Vol. 16, no. 1 (2013), pp.37-44.
https://search.emarefa.net/detail/BIM-380643
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nasir al-Din, Wail A.& Abd al-Rahman, Jamal M.& Abd al-Hamid, Ala al-Din Sad& Kamil, Amr A.. Interleukin-10 protects rat liver from CCl4-induced fibrogenesis via inhibition of hepatic stellate cells Ac-tivation. Suez Canal University Medical Journal. 2013. Vol. 16, no. 1, pp.37-44.
https://search.emarefa.net/detail/BIM-380643
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 43-44
رقم السجل
BIM-380643
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر