![](/images/graphics-bg.png)
Immunohistochemical pattern of tumor necrosis factor alpha (TNF-α) in lichen planus skin lesion
المؤلفون المشاركون
al-Saman, Shirin F.
Muhammad, Rushdi W.
Abd al-All, Huwayda S.
al-Ghawi, Hibah Allah A.
المصدر
Suez Canal University Medical Journal
العدد
المجلد 13، العدد 2 (31 ديسمبر/كانون الأول 2010)، ص ص. 16-23، 8ص.
الناشر
تاريخ النشر
2010-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Lichen planus (LP) is a chronic inflammatory mucocutaneous disorder with characteristic violaceous polygonal, flat-topped papules and plaques.
TNF-α, a 17 kDa protein, is a cytokine produced by a wide variety of cell types.
TNF-α is a cytokine that plays an important role in host defense, including immunoregulatory responses implicated in the pathogenesis of many inflammatory and autoimmune diseases.
Aim : detection of tissue expression pattern of TNF-α in lichen planus skin lesion.
Patients and Methods : This work involved lesional and normal control skin specimens divided into two groups ; group (I) included 29 specimens from patients suffering from cutaneous lichen planus, and group (II) included 29 normal individuals.
An immunohistochemical (IHC) technique was applied using a mouse monoclonal IgG1 100 μg / ml raised against purified full length native TNF-α, of human origin in order to study the expression pattern of TNF-α in lichen planus skin lesions and the normal skin.
Results : The majority (72.4 %) of the specimens in lichen planus group had moderate to strong TNF-α expression, while, (62.1 %) specimens of the normal control skin had negative TNF-α expression and (37.9 %) specimens had mild TNF-α expression in less than 5 % of the resident cells (p < 0.0001) which is highly significant and revealed that the expression of TNF-α in the lesional skin of patients with lichen planus is higher than the expression in the skin of the control group and this could be explained that TNF-α has an important role in the pathogenesis of lichen planus.
Conclusion : Immunohistochemical detection of TNF-α in lichen planus skin lesion is indicative of its involvement in LP immuopathogenesis.
This allows better understanding of LP pathogenic mechanism and suggests new modalities for its treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Rushdi W.& al-Saman, Shirin F.& Abd al-All, Huwayda S.& al-Ghawi, Hibah Allah A.. 2010. Immunohistochemical pattern of tumor necrosis factor alpha (TNF-α) in lichen planus skin lesion. Suez Canal University Medical Journal،Vol. 13, no. 2, pp.16-23.
https://search.emarefa.net/detail/BIM-380725
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Rushdi W.…[et al.]. Immunohistochemical pattern of tumor necrosis factor alpha (TNF-α) in lichen planus skin lesion. Suez Canal University Medical Journal Vol. 13, no. 2 (2010), pp.16-23.
https://search.emarefa.net/detail/BIM-380725
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Rushdi W.& al-Saman, Shirin F.& Abd al-All, Huwayda S.& al-Ghawi, Hibah Allah A.. Immunohistochemical pattern of tumor necrosis factor alpha (TNF-α) in lichen planus skin lesion. Suez Canal University Medical Journal. 2010. Vol. 13, no. 2, pp.16-23.
https://search.emarefa.net/detail/BIM-380725
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 23
رقم السجل
BIM-380725
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)