Steroid maintenance in repeat kidney transplantation : influence of induction agents on outcomes
المؤلفون المشاركون
Sureshkumar, Kalathil K.
Husayn, Sabihah M.
Nashshar, Khalid
Marcus, Richard J.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 25، العدد 4 (31 أغسطس/آب 2014)، ص ص. 741-749، 9ص.
الناشر
تاريخ النشر
2014-08-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
The influence of steroid maintenance on the outcomes of repeat kidney transplant (RKT) recipients with respect to induction type is unclear.
Using the Organ Procurement and Transplant Network / United Network of Organ Sharing (OPTN / UNOS) database, we identified patients (≥ 18 years) who underwent deceased donor RKT from January 2000 to December 2008 after receiving induction with rabbit-antithymocyte globulin (r-ATG), alemtuzumab or an IL-2 receptor blocker (IL-2B) and were discharged on a calcineurin inhibitor / mycophenolate mofetil regimen with or without steroids.
Of 5634 patients, 3643 received r-ATG (steroid = 3157, nosteroid = 486), 448 alemtuzumab (steroid = 196, no-steroid = 252) and 1543 an IL-2B (steroid = 1465, no-steroid = 78).
Unadjusted graft survivals were similar for the no-steroid versus steroid groups for induction with r-ATG [hazard ratio (HR) 0.85 and 95 % confidence interval (95 % CI) 0.70-1.03, P = 0.10], alemtuzumab (HR 0.76, 95 % CI 0.51-1.14, P = 0.18) and IL-2B (HR 0.77, 95 % CI 0.56-1.70, P = 0.23).
In the adjusted model, steroid use improved graft survival in alemtuzumab (HR 0.44, 95 % CI 0.25-0.76, P = 0.003) but not in the r-ATG (HR 0.86, 95 % CI 0.68-1.09, P = 0.21) or IL-2B (HR 0.98, 95 % CI 0.56-1.70, P = 0.94) groups.
Steroid use was associated with inferior patient survival in unadjusted (HR 1.30, 95 % CI 1.17-1.44, P < 0.001) and adjusted (HR 1.29, 95 % CI 1.14-1.45, P < 0.001) models for r-ATG induction, whereas this was not observed with alemtuzumab (unadjusted HR 1.11, 95 % CI 0.89-1.37, P = 0.36 ; adjusted HR 0.90, 95 % CI 0.68-1.20, P = 0.49) or IL-2B (unadjusted HR 1.01, 95 % CI 0.87-1.18, P = 0.87 ; adjusted HR 1.15, 95 % CI 0.97-1.38, P = 0.12) inductions.
Our study showed a graft survival benefit in the alemtuzumab-and patient death risk in the r-ATG-induced RKT recipients discharged on steroids.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sureshkumar, Kalathil K.& Husayn, Sabihah M.& Nashshar, Khalid& Marcus, Richard J.. 2014. Steroid maintenance in repeat kidney transplantation : influence of induction agents on outcomes. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 4, pp.741-749.
https://search.emarefa.net/detail/BIM-380877
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sureshkumar, Kalathil K.…[et al.]. Steroid maintenance in repeat kidney transplantation : influence of induction agents on outcomes. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 4 (2014), pp.741-749.
https://search.emarefa.net/detail/BIM-380877
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sureshkumar, Kalathil K.& Husayn, Sabihah M.& Nashshar, Khalid& Marcus, Richard J.. Steroid maintenance in repeat kidney transplantation : influence of induction agents on outcomes. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 4, pp.741-749.
https://search.emarefa.net/detail/BIM-380877
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 749
رقم السجل
BIM-380877
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر