A study of some biochemical parameters in blood serum of patients with chronic renal failure

الملخص EN

-This study was carried out on 55 patients(32males,23 females) with chronic renal failure aged (15-75)year admittedto al-dialysis unit in Kirkuk general hospital which compared with 35 healthy subjects as control group .The aim of this study is to investigate some biochemical parameters included urea ,creatinine ,uric acid, total protein ,triglycerides, total calcium ,inorganic phosphorus ,magnesium ,iron ,total iron binding capacity and ferritin in the serum of patients with chronic renal failure (CRF)before and after haemodialysis and to detect body mass index(BMI) and serum glucose in patientsbefore dialysisonly .

The results showed that there was significant increase(p<0.05) in the serum urea, creatinine ,uric acid ,triglyceride, magnesium and ferritin while revealed significant decrease in the levels oftotal protein, iron and total iron binding capacity inpatients before dialysis compared to the control group.Non-significant increase(p>0.05) is in serum glucose, phosphorus and body mass index in patients undergoing haemodialysis which was compared to the control group .There was non-significant decrease in the calcium in serum pre-dialysis patients than those in the control group.

In comparative study between pre and post haemodialysiscases,the serum urea,creatinine ,uric acid ,triglyceride, inorganic phosphorus and magnesium level showed significant decrease (p<0.05)in post dialysis compared to pre-dialysis ,while there was significant increase (p<0.01)in the serum total protein ,calcium ,iron ,total iron binding capacity and ferritin in post dialysis compared to pre dialysis .

Nosignificant changes(p>0.05) were observed in the levels of magnesium ,iron, total iron binding capacity and total protein whereas significant increase(p<0.01) observed in the levels of urea ,creatinine ,uric acid , triglyceride, inorganic phosphorus and ferritin in post dialysis compared with blood serum of normal individuals.There was significant decrease in serum calcium in post dialysis when compared with thecontrol group.

Keywords :chronic renal failure ,haemdialysis, elements