Vascular cell adhesion molecule-1, E-selectin and von Willebrand factor : role as surrogate markers of angiogenesis in breast cancer
العناوين الأخرى
أهمية جزئ التصاق الخلية بالأوعية الدموية-1، إي سيليكتين و عامل فون فيليبراند كدلالات لعملية تخليق أوعية دموية جديدة في مرض سرطان الثدي
المؤلفون المشاركون
Uthman, Muhammad Abd al-Qadir
Muhammad, Sumayyah Abd al-Rahman
المصدر
العدد
المجلد 30، العدد 3 (30 سبتمبر/أيلول 2006)، ص ص. 197-208، 12ص.
الناشر
تاريخ النشر
2006-09-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Angiogenesis, the development of new blood vessels from pre-existing vasculature, is a prerequisite for tumor growth and metastasis in breast cancer.
Surrogate markers for angiogenesis would be useful for studying the effectiveness of antiangiogenesis drugs.
We examined the potential of three glycoproteins: vascular cell adhesion molecule-1 (VCAM-1), endothelial selectin (E-Selectin), and von Willebrand factor (vWF), to serve as markers for angiogenesis.
Serum levels of VCAM-1, E-selectin and plasma vWF levels were measured by enzyme-linked immunosorbent assay in 54 women with different stages (1-IV) of breast cancer (12 women in stage I, 16 in stage II, 14 in stage HI and 12 in stage IV).
Their ages ranged from 25-70 years.
To investigate whether the concentration of these activated endothelial cell molecules are associated with breast cancer, the serum levels of soluble VCAM-l, E-selectin and plasma levels of vWF in women with breast cancer were compared with those of 22 healthy age-matched control women, we also examined whether levels of VCAM-1, E-selectin or vWF are associated with tumor progression and stage of breast cancer (early and advanced breast cancer).
The results revealed that levels of VCAM-1, E-selectin and vWF are elevated in breast cancer women, even in early stages when compared with control women.
Although plasma vWF and serum VCAM-1 levels were significantly elevated in advanced stages than early stages of breast cancer with a positive correlation with disease stage, E-selectin did not show a statistical difference, between different stages of breast cancer.
.
Conclusion: vWF, which is released by all endothelial cells, would be a pan-endothelial marker that would not accurately report angiogenesis and Serum soluble VCAM-l can be considered as an accurate marker of tumor angiogenesis in breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Sumayyah Abd al-Rahman& Uthman, Muhammad Abd al-Qadir. 2006. Vascular cell adhesion molecule-1, E-selectin and von Willebrand factor : role as surrogate markers of angiogenesis in breast cancer. Assiut Medical Journal،Vol. 30, no. 3, pp.197-208.
https://search.emarefa.net/detail/BIM-38284
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Sumayyah Abd al-Rahman& Uthman, Muhammad Abd al-Qadir. Vascular cell adhesion molecule-1, E-selectin and von Willebrand factor : role as surrogate markers of angiogenesis in breast cancer. Assiut Medical Journal Vol. 30, no. 3 (Sep. 2006), pp.197-208.
https://search.emarefa.net/detail/BIM-38284
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Sumayyah Abd al-Rahman& Uthman, Muhammad Abd al-Qadir. Vascular cell adhesion molecule-1, E-selectin and von Willebrand factor : role as surrogate markers of angiogenesis in breast cancer. Assiut Medical Journal. 2006. Vol. 30, no. 3, pp.197-208.
https://search.emarefa.net/detail/BIM-38284
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 206-207
رقم السجل
BIM-38284
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر