Effect of 1 % hydrogen peroxide (H2O2)‎ in drinking water on some parameters in adult male rabbits

الملخص EN

The present study was undertaken to investigate the effect of 1% of H2O2 on some biochemical markers related to oxidative stress,cardiac, hepatic and thyroid functions in adult male rabbit's.Twenty adult male rabbits were divided randomly into two groups (10 / group), the first (control) group and the second (T) group: animals were received 1 % hydrogen peroxide (H2O2)in drinking water for one month.At the end of the experiment, fasting blood samples were drawn by cardiac puncture technique from all experimental animals for measuring : a-serum concentration of total cholesterol(TC);triacylglycerol( TAG) ;low density lipoprotein –cholesterol (LDL-C) ; very low density lipoprotein-cholesterol (VLDL-C) and high density lipoprotein –cholesterol (HDL-C) b- serum alanine transaminase (ALT) ;aspartate transaminase (AST) and lactate dehydrogenase (LD) activities c- albumin and globulin concentrations.

d-Platelets count and prothrombin time e-serum glutathione (GSH) and malondialdehyde (MDA) concentrations.

F-serum thyroid stimulating hormone (TSH), triiodothronine (T3), tetraiodothyronine(T4) and glucose concentrations.

The results revealed that male rabbits receiving 1% H2O2 in drinking water for one month showed a significant increase(p < 0.01) in serum TC, TAG, LDL-C, VLDL-C and MDA concentrations, ALT, AST and LD activities and platelets count, and a significant decrease (p < 0.05) in serum HDL-C, GSH, albumin, globulin concentrations and prothrombin time comparing to control, besides significant decrease (p < 0.05) in serum T3 & T4 and significant increase (p < 0.05) in serum TSH, and glucose concentration were observed.

On conclusion, it has been found that exposure to1 % H2O2 of exerts deleterious effect on cardiac and hepatic functions, hypothyroidism and state of oxidative stress.