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Low-dose rabbit anti-thymoglobin globulin versus basiliximab for induction therapy in kidney transplantation
المؤلفون المشاركون
Kute, Vivek B.
Shah, Pankaj R.
Gumber, Manoj R.
Vanikar, Aruna V.
Patel, Himanshu V.
Trivedi, Hargovind L.
Engineer, Divyesh P.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 25، العدد 4 (31 أغسطس/آب 2014)، ص ص. 819-822، 4ص.
الناشر
تاريخ النشر
2014-08-31
دولة النشر
السعودية
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
We conducted a single-center prospective double-arm open-labeled study on kidney transplant patients from 2010 to 2011 to evaluate the efficacy of induction therapy using low, single-dose rabbit-antithymocyte globulin (r-ATG), 1.5 mg / kg on Day 0 (n = 80, 60 males, mean age 35.9 years), versus basiliximab (Interleukin-2 blocker) 20 mg on Days 0 and 4 (n = 20, 12 males, mean age 45.1 years) on renal allograft function in terms of serum creatinine (SCr), rejection and infection episodes and patient / graft survival and cost.
Demographic and post-transplant follow-up including immunosuppression was similar in both groups.
In the r-ATG group, donors were unrelated (spouse, n = 25), deceased (n = 31) and parents / siblings (others), with a mean HLA match of 1.58.
Donors in the basiliximab group were living unrelated (spouse, n = 15) and deceased (n = 5), with a mean HLA match of 1.56.
No patient / graft was lost in the r-ATG group over a mean of one year follow-up, and the mean SCr was 1.28 mg / dL with 7.5 % acute rejection (AR) episodes ; infections were also not observed.
In the basiliximab group, over the same period of follow-up, there was 95 % death-censored graft survival, and the mean SCr was 1.23 mg / dL with 10 % AR episodes.
One patient died due to bacterial pneumonia and one succumbed to coronary artery disease ; one graft was lost due to uncontrolled acute humoral and cellular rejection.
The cost of r-ATG and basiliximab were $600 and $2500, respectively.
We conclude that induction immunosuppressive therapy with a low-dose r-ATG may be a better option as compared with basiliximab in terms of graft function, survival and cost benefit in kidney transplant patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Patel, Himanshu V.& Kute, Vivek B.& Vanikar, Aruna V.& Shah, Pankaj R.& Gumber, Manoj R.& Engineer, Divyesh P.…[et al.]. 2014. Low-dose rabbit anti-thymoglobin globulin versus basiliximab for induction therapy in kidney transplantation. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 4, pp.819-822.
https://search.emarefa.net/detail/BIM-383503
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Patel, Himanshu V.…[et al.]. Low-dose rabbit anti-thymoglobin globulin versus basiliximab for induction therapy in kidney transplantation. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 4 (2014), pp.819-822.
https://search.emarefa.net/detail/BIM-383503
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Patel, Himanshu V.& Kute, Vivek B.& Vanikar, Aruna V.& Shah, Pankaj R.& Gumber, Manoj R.& Engineer, Divyesh P.…[et al.]. Low-dose rabbit anti-thymoglobin globulin versus basiliximab for induction therapy in kidney transplantation. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 4, pp.819-822.
https://search.emarefa.net/detail/BIM-383503
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 821-822
رقم السجل
BIM-383503
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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