Cross-talk between endothelin-1 and mineral metabolism in hemodialysis patients : a cross-sectional study
المؤلفون المشاركون
Zadah, Jamal Halaj
Ghorbanihaghjo, Amir
Rashtchizadeh, Nadirah
Argani, Hasan
Valizadeh, Shahnam
Halaj, Najat
Vatankhah, Amir Mansur
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 6 (30 يونيو/حزيران 2014)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2014-06-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Endotheline-1 (ET-1), an endothelial mediator, influences on mineral metabolism; especially vascular calcification in uremic patients. Objectives: The aim of the present study was to evaluate of ET-1, high-sensitivity C-reactive protein (hs-CRP) and mineral metabolites as the main factors for vascular calcification and inflammation in hemodialysis (HD) patients. Patients and Methods: In this cross-sectional study, 46 chronic stable HD patients were selected from nephrology departments of Tabriz University of Medical Sciences affiliated hospitals and classified based on phosphorus (P), Ca-P product (Ca × P) and intact Parathyroid Hormone (iPTH) levels.
We evaluated fasting serum ET-1and hs-CRP levels by the standard methods and compared with 46 healthy control subjects. Results: The levels of serum hs-CRP and ET-1 were significantly higher in the patient’s group compared with controls (4.40 ± 1.26 vs.
1.38 ± 1.61, P < 0.0001, and 2.31 ± 0.87 vs.
0.75 ± 0.48, P < 0.0001, respectively) and with regard to Ca × P product cut-off point (3.99 ± 0.78 vs.
5.33 ± 1.64, P < 0.0001, and 2 ± 0.73 vs.
3.04 ± 0.73, P < 0.0001 respectively).
ET-1 was correlated significantly with hs-CRP level (r = 0.776, P < 0.0001).
Serum P, Ca × P and iPTH levels directly and Ca indirectly were correlated with serum ET-1 in HD patients (r = 0.932, P < 0.0001, r = 0.766, P < 0.0001, r = 0.514, P < 0.0001, r = -0.538, P < 0.0001 respectively).
Multiple regression analysis demonstrated that serum P were independently associated with ET-1 levels (β = 0.932, P < 0.0001). Conclusions: Serum P and iPTH levels were independently associated with ET-1 and those may play a role in development of endothelial dysfunction in chronic kidney disease
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zadah, Jamal Halaj& Ghorbanihaghjo, Amir& Rashtchizadeh, Nadirah& Argani, Hasan& Valizadeh, Shahnam& Halaj, Najat…[et al.]. 2014. Cross-talk between endothelin-1 and mineral metabolism in hemodialysis patients : a cross-sectional study. Iranian Red Crescent Medical Journal،Vol. 16, no. 6, pp.1-7.
https://search.emarefa.net/detail/BIM-383550
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zadah, Jamal Halaj…[et al.]. Cross-talk between endothelin-1 and mineral metabolism in hemodialysis patients : a cross-sectional study. Iranian Red Crescent Medical Journal Vol. 16, no. 6 (Jun. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-383550
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zadah, Jamal Halaj& Ghorbanihaghjo, Amir& Rashtchizadeh, Nadirah& Argani, Hasan& Valizadeh, Shahnam& Halaj, Najat…[et al.]. Cross-talk between endothelin-1 and mineral metabolism in hemodialysis patients : a cross-sectional study. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 6, pp.1-7.
https://search.emarefa.net/detail/BIM-383550
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6-7
رقم السجل
BIM-383550
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر