Evaluation of the levels of IFN-gamma, IL-10 and copper in children with Visceral Leishmaniasis
المؤلفون المشاركون
Ghanim, Nahlah
Kamil, Mays N.
al-Najjar, Sabah
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 56، العدد 1 (31 مارس/آذار 2014)، ص ص. 90-94، 5ص.
الناشر
تاريخ النشر
2014-03-31
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Visceral Leishmaniasis( VL ) is a systemic infection of the reticulo- endothelial system that could affect the immune system and biochemical parameters like the concentration of Copper which may be significantly ve : The study aims to evaluate the level of cytokines (INF- y, IL-10 ) and trace element (Cu ) in Visceral Leishmaniasis in children after diagnosis.
patients and Methods : A total of 98 children, whose their ages ranged (6 menthes -5 years) were attending the Central Public Health Laboratory and Teaching Laboratories of Medical City, who were suspected to be infected with kala-azar, who were diagnosed by both IFAT technique and Rapid Kala-azar (r-K39) detecting test and trying to evaluate the level of cytokines (INF- y, IL-10) by ELISA and concentration of (Cu) by Atomic Absorption Technique Results : The dipstick test (r-K39) showed a high sensitivity of (92.1 %) compared to IFAT (73.6 %) with a specificity of 100 % for both tests.
Serum samples of 56 child with positive results in IFAT and rK39 test were used for the investigation of IL-10, IFN-y.
The mean levels of IL-10 (80.207 ± 77.54 Pg / ml) and IFN-y (5.426 ± 4.599 IU / ml) were highly significant increased in patients compared to healthy controls.
The mean level of serum Cu (171.54 ± 10.37 pg / dl) in VL patients.
Conclusions: This study showed that the (r-K39) dipstick test could be more sensitive than IFAT technique in the diagnosis of VL with a specificity of 100 % for both test according to clinical diagnosis.
Both IFN-y & IL-10 were significantly increased in VL patients as compared to controls group.
Copper concentration was significantly higher in VL patients than healthy controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kamil, Mays N.& al-Najjar, Sabah& Ghanim, Nahlah. 2014. Evaluation of the levels of IFN-gamma, IL-10 and copper in children with Visceral Leishmaniasis. Journal of the Faculty of Medicine Baghdad،Vol. 56, no. 1, pp.90-94.
https://search.emarefa.net/detail/BIM-385001
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kamil, Mays N.…[et al.]. Evaluation of the levels of IFN-gamma, IL-10 and copper in children with Visceral Leishmaniasis. Journal of the Faculty of Medicine Baghdad Vol. 56, no. 1 (2014), pp.90-94.
https://search.emarefa.net/detail/BIM-385001
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kamil, Mays N.& al-Najjar, Sabah& Ghanim, Nahlah. Evaluation of the levels of IFN-gamma, IL-10 and copper in children with Visceral Leishmaniasis. Journal of the Faculty of Medicine Baghdad. 2014. Vol. 56, no. 1, pp.90-94.
https://search.emarefa.net/detail/BIM-385001
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 93-94
رقم السجل
BIM-385001
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر